Reppert S M, Perlow M J, Artman H G, Ungerleider L G, Fisher D A, Klein D C
Brain Res. 1984 Jul 30;307(1-2):384-7. doi: 10.1016/0006-8993(84)90501-8.
The effects of lesions of the suprachiasmatic nuclei (SCN) on the circadian rhythm of oxytocin concentrations in cerebrospinal fluid (CSF) were examined in the rhesus monkey. In the two sham-operated animals, the rhythm was normally entrained to the daily light-dark cycle and persisted in constant lighting conditions at both 4 and 8 months after surgery. Similarly, the oxytocin rhythm was clearly manifested in the two animals with complete SCN ablation 4 months after surgery. At 8 months after surgery, however, the daily CSF rhythm was disrupted in one of the lesioned animals, while it persisted in the other animal. The data show that the SCN are not required for the expression of the daily rhythm of CSF oxytocin, suggesting that a circadian system outside the SCN normally generates the oxytocin rhythm.
在恒河猴中研究了视交叉上核（SCN）损伤对脑脊液（CSF）中催产素浓度昼夜节律的影响。在两只假手术动物中，该节律正常地与每日明暗周期同步，并在手术后4个月和8个月的持续光照条件下持续存在。同样，在手术后4个月，两只完全切除SCN的动物中催产素节律明显表现出来。然而，在手术后8个月，其中一只损伤动物的每日脑脊液节律被破坏，而在另一只动物中仍持续存在。数据表明，CSF催产素的每日节律表达不需要SCN，这表明SCN以外的昼夜节律系统通常会产生催产素节律。
