Balduini W, Abbracchio M P, Lombardelli G, Cattabeni F
Brain Res. 1984 Jul;317(1):133-6. doi: 10.1016/0165-3806(84)90149-4.
Treatment of pregnant rats with methylazoxymethanol (MAM) induces a marked microencephaly in the offspring. The striatum is one of the brain areas affected by treatment. We show that in striatum there is a 30% loss of dopamine (DA)-dependent adenylate-cyclase activity: this indicates that cells bearing type 1 DA receptors are affected by MAM treatment. Moreover, since kainic acid retains its neurotoxic activity, corticostriatal fibers do not seem to be affected, despite the dramatic reduction of cortex size.
用甲基氧化偶氮甲醇（MAM）处理怀孕大鼠会导致其后代出现明显的小头畸形。纹状体是受该处理影响的脑区之一。我们发现，纹状体中多巴胺（DA）依赖性腺苷酸环化酶活性丧失了30%：这表明表达1型DA受体的细胞受到了MAM处理的影响。此外，由于 kainic 酸保留了其神经毒性活性，尽管皮质大小显著减小，但皮质纹状体纤维似乎并未受到影响。
