Penchansky L
Cancer. 1984 Oct 1;54(7):1447-8. doi: 10.1002/1097-0142(19841001)54:7<1447::aid-cncr2820540737>3.0.co;2-8.
The bone marrow biopsy has an established role in the evaluation of nonhematologic malignancies in adults. The results of the trephine bone marrow biopsy (BMB) and bone marrow aspiration (BMA) in 42 children with solid tumors were reviewed. Bone marrow biopsies were done for the following indications: (1) "dry tap," (2) equivocal presence of tumor in the BMA, (3) definitely no tumor in the BMA, (4) protocol requirements. Of the 42 children, 19 (45%) had metastases in the BMB; 9 (21%) had a positive BMA and BMB, and 10 (23%) had a positive BMB and a questionable or negative BMA. Patients were divided into two groups, according to the presence or absence of metastases in the biopsy. Their clinical, hematologic, and pathologic findings were reviewed. Comparison was made between patients with and those without metastases. No single hematologic parameter was predictive of bone marrow metastases. Nevertheless, percentages of hemoglobin and platelet counts were lower in patients with metastases. This study indicates that, in children as in adults, aspiration and biopsy are complimentary procedures in the workup for metastases in patients with solid tumors.
骨髓活检在评估成人非血液系统恶性肿瘤方面具有既定作用。回顾了42例实体瘤患儿的环钻骨髓活检（BMB）和骨髓穿刺（BMA）结果。进行骨髓活检的指征如下：（1）“干抽”；（2）BMA中肿瘤存在情况不明确；（3）BMA中肯定无肿瘤；（4）方案要求。42例患儿中，19例（45%）BMB中有转移；9例（21%）BMA和BMB均为阳性，10例（23%）BMB为阳性且BMA可疑或为阴性。根据活检中有无转移将患者分为两组。回顾了他们的临床、血液学和病理学发现。对有转移和无转移的患者进行了比较。没有单一的血液学参数可预测骨髓转移。然而，有转移患者的血红蛋白和血小板计数百分比更低。本研究表明，与成人一样，在实体瘤患者转移灶检查中，穿刺和活检是互补的程序。
