Smith P, Jago R, Heath D
Cardiovasc Res. 1984 Aug;18(8):471-82. doi: 10.1093/cvr/18.8.471.
Carotid bodies from 21 normotensive Wistar albino rats were compared with those from 20 spontaneously hypertensive rats of the Okamoto strain. From serial histological sections the volume of the carotid bodies was estimated by Simpson's rule. Differential and absolute cell counts were also performed on the chief and elongated cells which surround them. The glomic vasculature was examined by light and electron microscopy. Although the carotid bodies of Okamoto rats were nearly three times as large as those of Wistar rats of comparable body weight, there was no difference in the proportion of the two types of cell. The organisation of glomic cells was also similar in the two strains. The main carotid body artery consists of a muscular tube with a valve-like cushion at its orifice. In the Okamoto rats branches of this artery were occluded by intimal proliferations of myofibroblasts embedded within a copious, loose matrix of acid mucopolysaccharide ground substance. These proliferations appeared to originate from intimal pads situated at the origins of many glomic arteries and arterioles. These findings are in sharp contrast to those in the hyperplastic human carotid body.
将21只血压正常的Wistar白化大鼠的颈动脉体与20只冈本品系的自发性高血压大鼠的颈动脉体进行了比较。根据连续组织学切片，用辛普森法则估算颈动脉体的体积。还对主细胞及其周围的细长细胞进行了差异细胞计数和绝对细胞计数。通过光学显微镜和电子显微镜检查了球状体脉管系统。尽管冈本大鼠的颈动脉体几乎是体重相当的Wistar大鼠颈动脉体的三倍大，但两种类型细胞的比例并无差异。两种品系中球状体细胞的组织也相似。颈动脉体主要动脉由一根肌性管道组成，其开口处有一个瓣膜样垫子。在冈本大鼠中，该动脉的分支被包埋在大量疏松酸性粘多糖基质中的肌成纤维细胞内膜增生所阻塞。这些增生似乎起源于许多球状体动脉和小动脉起始处的内膜垫。这些发现与增生性人类颈动脉体的发现形成鲜明对比。
