Moscato G, Naldi L, Candura F
Clin Allergy. 1984 Jul;14(4):355-61. doi: 10.1111/j.1365-2222.1984.tb02216.x.
Two cases of bronchial asthma due to spiramycin in workers of a pharmaceutical factory are reported. The subjects complained of cough, breathlessness and symptoms of asthma at work when coming into contact with spiramycin's powder. The symptoms cleared when away from work for more than 3 or 4 days. Inhalation challenge tests by aerosolization of solutions of spiramycin reproduced asthmatic reactions dual in type in both patients, the immediate component of the response has not been previously described for this antibiotic. Furthermore, one of the patients developed an immediate asthmatic reaction also after inhalation of a solution of adipic acid, and additive to bind spiramycin and diminish its irritant action. The reaction was obtained at a non-irritant concentration of the acid, was reproducible and inhibited by previous administration of sodium cromoglycate: this finding and the failure to elicit the reaction in the other patient suggest a hypersensitivity reaction to this substance.
报告了制药厂工人中因螺旋霉素引起的两例支气管哮喘病例。受试者在接触螺旋霉素粉末时工作中出现咳嗽、呼吸急促和哮喘症状。离开工作岗位3至4天以上时症状消失。通过雾化螺旋霉素溶液进行吸入激发试验在两名患者中均重现了双相哮喘反应，该抗生素的反应速发成分此前未曾有过描述。此外，其中一名患者吸入己二酸溶液（一种用于结合螺旋霉素并减轻其刺激作用的添加剂）后也出现了速发哮喘反应。该反应在酸的非刺激浓度下出现，可重现且可被预先给予色甘酸钠抑制：这一发现以及另一名患者未引发该反应表明对该物质存在超敏反应。
