Paggiaro P L, Loi A M, Toma G
Clin Allergy. 1979 Nov;9(6):571-4. doi: 10.1111/j.1365-2222.1979.tb00481.x.
A case of bronchial asthma and dermatitis due to spiramycin is described in a non-atopic woman who worked as a chick breeder and handling poultry feed containing antibiotic or chemoterapic drugs including spiramycin, chlortetracycline and sulfadimethoxine. Patch tests showed a vigorous delayed reaction to spiramycin. Inhalation challenge test with the chick feed containing spiramycin reproduced symptoms of late asthmatic response (FEV1 fell by 14% and FEF25-75 by 25% within the 4th and 6th hour) with leucocytosis. No significant modification of FEV1 and FEF25-75 was observed within 24 hours after challenge with chick feeds containing other antibiotic or chemotherapeutic agents but not spiramycin. On leaving her job, the patient had no further skin reactions or bronchial asthma episodes. This case suggests that allergic reactions to a chemical product may involve both type III and IV hypersensitivity.
一名非特应性女性病例报告，该女性从事雏鸡饲养员工作，接触含有抗生素或化疗药物（包括螺旋霉素、金霉素和磺胺二甲氧嘧啶）的家禽饲料后，出现支气管哮喘和皮炎。斑贴试验显示对螺旋霉素有强烈的迟发性反应。用含螺旋霉素的雏鸡饲料进行吸入激发试验重现了迟发性哮喘反应症状（第4小时和第6小时内FEV1下降14%，FEF25 - 75下降25%），伴有白细胞增多。用不含螺旋霉素但含其他抗生素或化疗药物的雏鸡饲料激发后24小时内，未观察到FEV1和FEF25 - 75有明显变化。离职后，该患者未再出现皮肤反应或支气管哮喘发作。该病例表明，对化学产品的过敏反应可能涉及III型和IV型超敏反应。
