Borgna-Pignatti C, De Stefano P, Barone F, Concia E
Eur J Pediatr. 1984 Jun;142(2):83-5. doi: 10.1007/BF00445583.
Compliance with penicillin prophylaxis after splenectomy was studied in 42 thalassemic children and adolescents. Urine samples were tested five times per patient for the presence of penicillin by the Sarcina lutea inhibition test. Only 7% of patients were found to be absolute noncompliers, while an additional 14% had a compliance considered to be insufficient. Noncompliers tended to have been splenectomized more than 5 years before, while couples of affected siblings were uniformly full-compliers. No relation was found with age, presence of healthy siblings in the household, chronic disease or previous severe infections. Knowledge of the risks of severe infection after splenectomy was uniformly good. We conclude that compliance with penicillin prophylaxis in splenectomized thalassemics is good (79%) and that close contact between patients and medical staff is important in its promotion.
对42名地中海贫血儿童和青少年进行了脾切除术后青霉素预防治疗依从性的研究。通过藤黄八叠球菌抑制试验，对每位患者的尿液样本进行了5次青霉素检测。仅发现7%的患者完全不依从，另有14%的患者依从性不足。不依从者往往在脾切除术后5年以上接受手术，而患病的兄弟姐妹夫妇均完全依从。未发现与年龄、家庭中健康兄弟姐妹的存在、慢性病或既往严重感染有关。对脾切除术后严重感染风险的认知普遍良好。我们得出结论，脾切除的地中海贫血患者对青霉素预防治疗的依从性良好（79%），患者与医务人员之间的密切接触对促进依从性很重要。
