Arigliani R, Molinari A C, Favareto F, Traverso T, Melevendi C, Boeri E, Mori P G
IV Divisione di Pediatria, Istituto Giannina Gaslini, Genova, Italia.
Pediatr Med Chir. 1987 May-Jun;9(3):281-2.
To investigate the effective usefulness of penicillin prophylaxis in splenectomized patients, we retrospectively focused on a group of sixty-two splenectomized patients affected by thalassemia major. Thirty-six out of 62 has been receiving monthly 1.200.000 Us. of benzathine-penicillin as prophylaxis. The remaining 26 did not receive prophylaxis, but was treated with antibacterial drugs as soon as symptoms of upper respiratory tract infection occurred. During a total period of eleven years of observation we did not observe any pneumococcal sepsis; the incidence of bacterial infections within the two groups is not different. We conclude for the uselessness of penicillin prophylaxis in splenectomized beta-thalassemic patients.
为研究青霉素预防在脾切除患者中的有效性，我们回顾性地关注了一组62例患有重型地中海贫血的脾切除患者。62例患者中有36例每月接受120万单位苄星青霉素作为预防用药。其余26例未接受预防治疗，但在上呼吸道感染症状出现时使用抗菌药物治疗。在总共11年的观察期内，我们未观察到任何肺炎球菌败血症；两组内细菌感染的发生率无差异。我们得出结论，青霉素预防对脾切除的β地中海贫血患者无效。
