Jackson S H, Wiffen J K, Johnston A, Peverel-Cooper C A
Eur J Clin Pharmacol. 1984;26(5):635-7. doi: 10.1007/BF00543500.
Six healthy volunteers received an iv infusion of 317 mg lysine theophylline (equivalent to 197 mg anhydrous theophylline) in order to calculate theophylline clearance by standard methods. They subsequently received a 20 minute inhalation of nebulised lysine theophylline. Serum and salivary theophylline concentrations were measured and all saliva was collected for the first hour. From these concentrations estimates were made of the distribution of theophylline into the blood and saliva with 40% to 94% identified in the blood. Very high salivary concentrations were reached during the inhalation phase with saliva: serum concentration ratios of between 60 and 1600.
六名健康志愿者接受了静脉输注317毫克赖氨酸茶碱（相当于197毫克无水茶碱），以便通过标准方法计算茶碱清除率。随后，他们接受了20分钟的雾化赖氨酸茶碱吸入。测量了血清和唾液中的茶碱浓度，并在第一个小时收集了所有唾液。根据这些浓度估算了茶碱在血液和唾液中的分布情况，其中40%至94%存在于血液中。在吸入阶段唾液中的浓度非常高，唾液与血清浓度比在60至1600之间。
