Kandt D, Ivainsky H, Sehrt I
Respiration. 1981;42(4):278-82. doi: 10.1159/000194443.
We investigated aethophylline and aminophylline aerosols using a jet or an ultrasonic nebulizer in 51 patients suffering from NSLD with reversible bronchospasm. FEV1 was controlled in fixed intervals, and the patients were questioned about their subjective statements. A bronchospasmolytic test with isoprenaline spray at the end was performed to demonstrate the actual reversibility of the bronchospasm. Only theophylline aerosols produced by a ultrasonic nebulizer had a subjective and a functional efficacy. Theophylline aerosols of a 2.5% solution were proved to be better than aerosols of a 5% solution, but in comparison with the used sympathicomimetic drug isoprenaline spray, they were less effective. There was a good correlation with the subjective statements of the patients concerning the clinical effects. The concentration of the therapeutic aerosol seemed to be an important factor for the local tolerance and the ventilatory effects, measurable serum levels of theophylline could not be found. Therefore, the topical action of theophylline is considered to be responsible for the clinical effect.
我们使用喷射式或超声雾化器，对51例患有非特异性间质性肺炎（NSLD）且伴有可逆性支气管痉挛的患者进行了茶碱乙二胺和氨茶碱气雾剂的研究。每隔固定时间测量一次第一秒用力呼气量（FEV1），并询问患者的主观感受。最后用异丙肾上腺素喷雾进行支气管解痉试验，以证明支气管痉挛的实际可逆性。只有超声雾化器产生的茶碱气雾剂具有主观和功能疗效。事实证明，2.5%溶液的茶碱气雾剂比5%溶液的气雾剂效果更好，但与使用的拟交感神经药物异丙肾上腺素喷雾相比，其效果较差。患者关于临床效果的主观感受与之有良好的相关性。治疗气雾剂的浓度似乎是局部耐受性和通气效果的一个重要因素，未发现可测量的血清茶碱水平。因此，茶碱的局部作用被认为是产生临床效果的原因。
