Satchell D, Smith R
Eur J Pharmacol. 1984 Jun 1;101(3-4):243-7. doi: 10.1016/0014-2999(84)90163-8.
Guinea-pig tracheae were cut into transverse strips or spirals and although there is only minor difference in the angle of cut, the former preparations relaxed in response to ATP and adenosine while the latter contracted. Theophylline antagonised both types of response suggesting involvement of P1-purinoceptors. Dipyridamole potentiated inhibitory responses to ATP and adenosine in transverse strips but reversed contractile responses to ATP and adenosine in spiral strips. Antagonism of contractions to ATP and adenosine in spiral strips by hyoscine is consistent with an action of adenosine on cholinergic nerves. The likelihood that ATP rapidly forms adenosine by which it acts is discussed.
将豚鼠气管切成横向条带或螺旋条带，尽管切割角度仅有微小差异，但前者制剂对ATP和腺苷产生舒张反应，而后者则收缩。茶碱拮抗这两种反应类型，提示P1嘌呤受体参与其中。双嘧达莫增强横向条带对ATP和腺苷的抑制反应，但逆转螺旋条带对ATP和腺苷的收缩反应。东莨菪碱对螺旋条带中ATP和腺苷收缩反应的拮抗作用与腺苷对胆碱能神经的作用一致。文中讨论了ATP迅速形成其起作用的腺苷的可能性。
