腺苷、三磷酸腺苷及电刺激对豚鼠胃底条的舒张作用：茶碱或ATP处理无拮抗作用
Relaxation of guinea-pig fundic strip by adenosine, adenosine triphosphate and electrical stimulation: lack of antagonism by theophylline or ATP treatment.
作者信息
Baer H P, Frew R
出版信息
Br J Pharmacol. 1979 Oct;67(2):293-9. doi: 10.1111/j.1476-5381.1979.tb08679.x.
Abstract
1 Theophylline relaxed isolated strips of guinea-pig stomach fundus in a dose-dependent manner; above 50 to 100 microM responses showed no fade for up to 90 min. 2 Relaxant responses to adenosine, adenosine triphosphate (ATP), noradrenaline, and to electric field stimulation of non-adrenergic inhibitory nerves were not affected in a significant manner in the presence of 50 microM theophylline. 3 In tissues which showed complete fade of initial responses in the continued presence of 50 microM ATP, the effects of stimulation of non-adrenergic inhibitory nerves remained unaltered, suggesting that the ATP receptor has no function in non-adrenergic inhibitory transmission in this tissue. 4 These findings are opposite to those of Okwuasaba, Hamilton & Cook (1977), who claimed that 50 microM theophylline almost fully inhibited relaxation induced by adenosine ATP and nerve stimulation and that ATP-induced fade also abolished sensitivity to inhibitory nerve stimulation.
摘要
- 茶碱以剂量依赖的方式使豚鼠胃底的离体肌条松弛；在50至100微摩尔以上时，反应在长达90分钟内无衰减。2. 在存在50微摩尔茶碱的情况下，对腺苷、三磷酸腺苷（ATP）、去甲肾上腺素以及对非肾上腺素能抑制神经的电场刺激的松弛反应未受到显著影响。3. 在持续存在50微摩尔ATP时最初反应完全衰减的组织中，非肾上腺素能抑制神经刺激的效应保持不变，这表明ATP受体在该组织的非肾上腺素能抑制传递中不起作用。4. 这些发现与Okwuasaba、Hamilton和Cook（1977年）的发现相反，他们声称50微摩尔茶碱几乎完全抑制了由腺苷、ATP和神经刺激诱导的松弛，并且ATP诱导的衰减也消除了对抑制性神经刺激的敏感性。
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Relaxation of guinea-pig fundic strip by adenosine, adenosine triphosphate and electrical stimulation: lack of antagonism by theophylline or ATP treatment.腺苷、三磷酸腺苷及电刺激对豚鼠胃底条的舒张作用：茶碱或ATP处理无拮抗作用
Br J Pharmacol. 1979 Oct;67(2):293-9. doi: 10.1111/j.1476-5381.1979.tb08679.x.
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本文引用的文献
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8
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