腺苷、三磷酸腺苷及电刺激对豚鼠胃底条的舒张作用：茶碱或ATP处理无拮抗作用
Relaxation of guinea-pig fundic strip by adenosine, adenosine triphosphate and electrical stimulation: lack of antagonism by theophylline or ATP treatment.
作者信息
Baer H P, Frew R
出版信息
Br J Pharmacol. 1979 Oct;67(2):293-9. doi: 10.1111/j.1476-5381.1979.tb08679.x.
Abstract
1 Theophylline relaxed isolated strips of guinea-pig stomach fundus in a dose-dependent manner; above 50 to 100 microM responses showed no fade for up to 90 min. 2 Relaxant responses to adenosine, adenosine triphosphate (ATP), noradrenaline, and to electric field stimulation of non-adrenergic inhibitory nerves were not affected in a significant manner in the presence of 50 microM theophylline. 3 In tissues which showed complete fade of initial responses in the continued presence of 50 microM ATP, the effects of stimulation of non-adrenergic inhibitory nerves remained unaltered, suggesting that the ATP receptor has no function in non-adrenergic inhibitory transmission in this tissue. 4 These findings are opposite to those of Okwuasaba, Hamilton & Cook (1977), who claimed that 50 microM theophylline almost fully inhibited relaxation induced by adenosine ATP and nerve stimulation and that ATP-induced fade also abolished sensitivity to inhibitory nerve stimulation.
摘要
- 茶碱以剂量依赖的方式使豚鼠胃底的离体肌条松弛；在50至100微摩尔以上时，反应在长达90分钟内无衰减。2. 在存在50微摩尔茶碱的情况下，对腺苷、三磷酸腺苷（ATP）、去甲肾上腺素以及对非肾上腺素能抑制神经的电场刺激的松弛反应未受到显著影响。3. 在持续存在50微摩尔ATP时最初反应完全衰减的组织中，非肾上腺素能抑制神经刺激的效应保持不变，这表明ATP受体在该组织的非肾上腺素能抑制传递中不起作用。4. 这些发现与Okwuasaba、Hamilton和Cook（1977年）的发现相反，他们声称50微摩尔茶碱几乎完全抑制了由腺苷、ATP和神经刺激诱导的松弛，并且ATP诱导的衰减也消除了对抑制性神经刺激的敏感性。
相似文献
1
Relaxation of guinea-pig fundic strip by adenosine, adenosine triphosphate and electrical stimulation: lack of antagonism by theophylline or ATP treatment.腺苷、三磷酸腺苷及电刺激对豚鼠胃底条的舒张作用：茶碱或ATP处理无拮抗作用
Br J Pharmacol. 1979 Oct;67(2):293-9. doi: 10.1111/j.1476-5381.1979.tb08679.x.
2
Inhibition of fundic strips from guinea-pig stomach: the effect of theophylline on responses to adenosine, ATP and intramural nerve stimulation.豚鼠胃底条的抑制作用：茶碱对腺苷、ATP及壁内神经刺激反应的影响
Eur J Pharmacol. 1980 May 16;63(4):259-65. doi: 10.1016/0014-2999(80)90253-8.
3
Theophylline antagonizes some effects of purines in the intestine but not those of intramural inhibitory nerve stimulation.茶碱可拮抗嘌呤在肠道中的某些作用，但不能拮抗壁内抑制性神经刺激的作用。
Br J Pharmacol. 1979 Oct;67(2):301-8. doi: 10.1111/j.1476-5381.1979.tb08680.x.
4
Adenosine causes contractions in spiral strips and relaxations in transverse strips of guinea-pig trachea: studies on mechanism of action.腺苷可使豚鼠气管螺旋条收缩，使横条松弛：作用机制研究。
Eur J Pharmacol. 1984 Jun 1;101(3-4):243-7. doi: 10.1016/0014-2999(84)90163-8.
5
ATP- and adenosine-induced relaxation of the smooth muscle of the pig urethra.ATP和腺苷诱导猪尿道平滑肌舒张
BJU Int. 2005 Dec;96(9):1386-91. doi: 10.1111/j.1464-410X.2005.05853.x.
6
Dual action of high energy adenine nucleotides in comparison with responses evoked by other adenine derivatives and intramural nerve stimulation on smooth muscle.与其他腺嘌呤衍生物及壁内神经刺激对平滑肌所诱发的反应相比，高能腺嘌呤核苷酸的双重作用。
Eur J Pharmacol. 1981 Sep 11;74(2-3):175-80. doi: 10.1016/0014-2999(81)90528-8.
7
Non-cholinergic, non-adrenergic responses to nerve stimulation of different regions of the guinea-pig small intestine.豚鼠小肠不同区域神经刺激的非胆碱能、非肾上腺素能反应。
Naunyn Schmiedebergs Arch Pharmacol. 1982 May;319(2):108-14. doi: 10.1007/BF00503921.
8
Relaxations of guinea-pig fundic strip by adenosine, adenine nucleotides and electrical stimulation: antagonsism by theophylline and desensitization to adenosine and its derivatives.腺苷、腺嘌呤核苷酸及电刺激对豚鼠胃底条的舒张作用：茶碱的拮抗作用以及对腺苷及其衍生物的脱敏作用
Eur J Pharmacol. 1977 Dec 1;46(3):181-98. doi: 10.1016/0014-2999(77)90333-8.
9
Neither vasoactive intestinal peptide (VIP) nor purine derivatives may mediate non-adrenergic tracheal inhibition.血管活性肠肽（VIP）和嘌呤衍生物都不能介导非肾上腺素能性气管抑制。
Acta Physiol Scand. 1984 Dec;122(4):589-98. doi: 10.1111/j.1748-1716.1984.tb07548.x.
10
Apamin, a nonspecific antagonist of smooth muscle relaxants.蜂毒明肽，一种平滑肌松弛剂的非特异性拮抗剂。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Feb;311(1):105-7. doi: 10.1007/BF00500310.
引用本文的文献
1
Purinergic signalling in the gastrointestinal tract and related organs in health and disease.健康与疾病状态下胃肠道及相关器官中的嘌呤能信号传导
Purinergic Signal. 2014 Mar;10(1):3-50. doi: 10.1007/s11302-013-9397-9. Epub 2013 Dec 4.
2
Contribution of prostaglandins and thromboxanes to the adenosine and ATP-induced contraction of guinea-pig isolated trachea.前列腺素和血栓素对豚鼠离体气管中腺苷和ATP诱导收缩的作用。
Br J Pharmacol. 1982 Sep;77(1):39-44. doi: 10.1111/j.1476-5381.1982.tb09266.x.
3
Neither a purine nor VIP is the mediator of inhibitory nerves of opossum oesophageal smooth muscle.嘌呤和血管活性肠肽都不是负鼠食管平滑肌抑制性神经的介质。
J Physiol. 1983 Mar;336:243-60. doi: 10.1113/jphysiol.1983.sp014579.
4
Adenosine and ATP effects on isolated guinea pig gallbladder.腺苷和三磷酸腺苷对离体豚鼠胆囊的作用。
Pflugers Arch. 1983 Sep;399(1):42-5. doi: 10.1007/BF00652520.
5
Non-cholinergic, non-adrenergic responses to nerve stimulation of different regions of the guinea-pig small intestine.豚鼠小肠不同区域神经刺激的非胆碱能、非肾上腺素能反应。
Naunyn Schmiedebergs Arch Pharmacol. 1982 May;319(2):108-14. doi: 10.1007/BF00503921.
6
Neural inhibition of gastrointestinal smooth muscle motility in guinea-pigs.豚鼠胃肠道平滑肌运动的神经抑制作用
Gastroenterol Jpn. 1987 Dec;22(6):690-7. doi: 10.1007/BF02776740.
7
Gastric motor responses elicited by vagal stimulation and purine compounds in the atropine-treated rabbit.阿托品处理的家兔中迷走神经刺激和嘌呤化合物引发的胃运动反应
Br J Pharmacol. 1988 Aug;94(4):1157-66. doi: 10.1111/j.1476-5381.1988.tb11634.x.
8
Theophylline antagonizes some effects of purines in the intestine but not those of intramural inhibitory nerve stimulation.茶碱可拮抗嘌呤在肠道中的某些作用，但不能拮抗壁内抑制性神经刺激的作用。
Br J Pharmacol. 1979 Oct;67(2):301-8. doi: 10.1111/j.1476-5381.1979.tb08680.x.
本文引用的文献
1
Inhibition of coronary vasodilating action of dipyridamole and adenosine by aminophylline in the dog.氨茶碱对犬双嘧达莫和腺苷冠状动脉舒张作用的抑制
Circ Res. 1970 Jun;26(6):743-52. doi: 10.1161/01.res.26.6.743.
2
Purinergic nerves.嘌呤能神经
Pharmacol Rev. 1972 Sep;24(3):509-81.
3
Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut.有证据表明三磷酸腺苷或一种相关核苷酸是肠道中非肾上腺素能抑制性神经释放的递质物质。
Br J Pharmacol. 1970 Dec;40(4):668-88. doi: 10.1111/j.1476-5381.1970.tb10646.x.
4
[Antagonism of circulation effect of adenosine by theophylline].[茶碱对腺苷循环效应的拮抗作用]
Arzneimittelforschung. 1970 Mar;20(3):372-7.
5
Coronary responses to dilating substances and competitive inhibition by theophylline in the isolated perfused guinea pig heart.离体灌注豚鼠心脏对舒张物质的冠脉反应及茶碱的竞争性抑制作用。
Pflugers Arch. 1975 Jul 28;358(3):213-24. doi: 10.1007/BF00587218.
6
Transport of nucleosides.
Ann N Y Acad Sci. 1975 Aug 8;255:402-11. doi: 10.1111/j.1749-6632.1975.tb29248.x.
7
Relaxations of guinea-pig fundic strip by adenosine, adenine nucleotides and electrical stimulation: antagonsism by theophylline and desensitization to adenosine and its derivatives.腺苷、腺嘌呤核苷酸及电刺激对豚鼠胃底条的舒张作用：茶碱的拮抗作用以及对腺苷及其衍生物的脱敏作用
Eur J Pharmacol. 1977 Dec 1;46(3):181-98. doi: 10.1016/0014-2999(77)90333-8.
8
Theophylline antagonizes some effects of purines in the intestine but not those of intramural inhibitory nerve stimulation.茶碱可拮抗嘌呤在肠道中的某些作用，但不能拮抗壁内抑制性神经刺激的作用。
Br J Pharmacol. 1979 Oct;67(2):301-8. doi: 10.1111/j.1476-5381.1979.tb08680.x.
9
Adenosine inhibition of isolated rabbit ileum and antagonism by theophylline.
J Pharmacol Exp Ther. 1976 Oct;199(1):208-15.
10
The effects of uptake1 on alpha-adrenoceptor antagonist potency in dog saphenous vein.摄取1对犬隐静脉中α-肾上腺素能受体拮抗剂效价的影响。
Br J Pharmacol. 1978 Aug;63(4):665-9. doi: 10.1111/j.1476-5381.1978.tb17280.x.
Zotero 插件