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1
Contribution of prostaglandins and thromboxanes to the adenosine and ATP-induced contraction of guinea-pig isolated trachea.前列腺素和血栓素对豚鼠离体气管中腺苷和ATP诱导收缩的作用。
Br J Pharmacol. 1982 Sep;77(1):39-44. doi: 10.1111/j.1476-5381.1982.tb09266.x.
2
Discrimination by dipyridamole of two types of responses to adenosine and ATP of the carbachol-induced contraction of guinea-pig trachea.双嘧达莫对豚鼠气管卡巴胆碱诱导收缩对腺苷和ATP的两种反应类型的鉴别
Eur J Pharmacol. 1983 May 20;90(1):29-34. doi: 10.1016/0014-2999(83)90210-8.
3
Contractile effects of nucleotides in guinea pig isolated, perfused trachea: involvement of respiratory epithelium, prostanoids and Na+ and Cl- channels.核苷酸对豚鼠离体灌注气管的收缩作用：呼吸道上皮、前列腺素以及钠离子和氯离子通道的参与
J Pharmacol Exp Ther. 1993 Jan;264(1):210-6.
4
Relaxant effects of nucleotides in guinea pig isolated, perfused trachea: lack of involvement of prostanoids, Cl- channels and adenosine.核苷酸对豚鼠离体灌注气管的舒张作用：不涉及前列腺素、氯离子通道和腺苷。
J Pharmacol Exp Ther. 1993 Jan;264(1):217-20.
5
Adenosine causes contractions in spiral strips and relaxations in transverse strips of guinea-pig trachea: studies on mechanism of action.腺苷可使豚鼠气管螺旋条收缩，使横条松弛：作用机制研究。
Eur J Pharmacol. 1984 Jun 1;101(3-4):243-7. doi: 10.1016/0014-2999(84)90163-8.
6
Contractile effect of alpha,beta-methylene ATP on the guinea-pig isolated trachea.α,β-亚甲基ATP对豚鼠离体气管的收缩作用。
Fundam Clin Pharmacol. 1992;6(3):135-44. doi: 10.1111/j.1472-8206.1992.tb00104.x.
7
Suppression by adenine compounds of histamine-induced contraction in isolated guinea pig tracheal rings.腺嘌呤化合物对组胺诱导的豚鼠离体气管环收缩的抑制作用。
Pharmacology. 1982;24(5):283-6. doi: 10.1159/000137608.
8
Purine receptors and guinea-pig trachea: evidence for a direct action of ATP.嘌呤受体与豚鼠气管：ATP直接作用的证据
Br J Pharmacol. 1988 Nov;95(3):689-94. doi: 10.1111/j.1476-5381.1988.tb11694.x.
9
Contribution of prostaglandins to the adenosine triphosphate-induced contraction of rabbit urinary bladder.前列腺素对三磷酸腺苷诱导的兔膀胱收缩的作用
Br J Pharmacol. 1980 Nov;70(3):443-52. doi: 10.1111/j.1476-5381.1980.tb08722.x.
10
Possible involvement of prostaglandins in the action of ATP on guinea-pig uterus.前列腺素可能参与ATP对豚鼠子宫的作用。
J Pharmacol Exp Ther. 1979 Oct;211(1):104-11.

引用本文的文献

1
Histamine, carbachol, and serotonin induce hyperresponsiveness to ATP in guinea pig tracheas: involvement of COX-2 pathway.组胺、卡巴胆碱和 5-羟色胺诱导豚鼠气管对 ATP 产生超反应性：COX-2 途径的参与。
Pflugers Arch. 2013 Aug;465(8):1171-9. doi: 10.1007/s00424-013-1253-9. Epub 2013 Mar 10.
2
In airways ATP refills sarcoplasmic reticulum via P2X smooth muscle receptors and induces contraction through P2Y epithelial receptors.在气道中，ATP 通过 P2X 平滑肌受体补充肌浆网，并通过 P2Y 上皮受体诱导收缩。
Pflugers Arch. 2011 Feb;461(2):261-75. doi: 10.1007/s00424-010-0886-1. Epub 2010 Oct 15.
3
Biphasic effect of extracellular ATP on human and rat airways is due to multiple P2 purinoceptor activation.细胞外ATP对人和大鼠气道的双相作用归因于多种P2嘌呤受体的激活。
Respir Res. 2005 Dec 8;6(1):143. doi: 10.1186/1465-9921-6-143.
4
Contractile responses to adenosine, R-PIA and ovalbumen in passively sensitized guinea-pig isolated airways.被动致敏豚鼠离体气道对腺苷、R - 苯基异丙基腺苷和卵清蛋白的收缩反应。
Br J Pharmacol. 2002 Nov;137(6):729-38. doi: 10.1038/sj.bjp.0704902.
5
Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease.关于腺苷高反应性在哮喘和慢性阻塞性肺疾病中的价值的不断演变的概念。
Thorax. 2002 Jul;57(7):649-54. doi: 10.1136/thorax.57.7.649.
6
Adenosine monophosphate and histamine induced bronchoconstriction: repeatability and protection by terbutaline.腺苷一磷酸和组胺诱导的支气管收缩：可重复性及特布他林的保护作用
Thorax. 1997 Mar;52(3):239-43. doi: 10.1136/thx.52.3.239.
7
Effects of purinoceptor agonists on cytosolic Ca2+ concentration in swine tracheal smooth muscle cells in culture.嘌呤受体激动剂对培养的猪气管平滑肌细胞胞质钙离子浓度的影响。
Br J Pharmacol. 1996 Oct;119(3):539-44. doi: 10.1111/j.1476-5381.1996.tb15705.x.
8
Contraction of the rat isolated spleen mediated by adenosine A1 receptor activation.腺苷A1受体激活介导的大鼠离体脾脏收缩
Br J Pharmacol. 1993 Aug;109(4):1059-63. doi: 10.1111/j.1476-5381.1993.tb13729.x.
9
Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects.吸入腺苷和鸟苷对正常人和哮喘患者气道阻力的影响。
Br J Clin Pharmacol. 1983 Feb;15(2):161-5. doi: 10.1111/j.1365-2125.1983.tb01481.x.
10
The effects of epithelium removal on the sensitivity of guinea-pig isolated trachealis to bronchodilator drugs.上皮去除对豚鼠离体气管对支气管扩张药物敏感性的影响。
Br J Pharmacol. 1986 Oct;89(2):407-14. doi: 10.1111/j.1476-5381.1986.tb10274.x.

本文引用的文献

1
Contribution of prostaglandins to the adenosine triphosphate-induced contraction of rabbit urinary bladder.前列腺素对三磷酸腺苷诱导的兔膀胱收缩的作用
Br J Pharmacol. 1980 Nov;70(3):443-52. doi: 10.1111/j.1476-5381.1980.tb08722.x.
2
Metabolism of arachidonic acid and its endoperoxide (PGH2) to myotropic products in guinea-pig and rabbit isolated lungs.花生四烯酸及其内过氧化物（PGH2）在豚鼠和兔离体肺中向致肌性产物的代谢。
Br J Pharmacol. 1980 Jul;69(3):479-89. doi: 10.1111/j.1476-5381.1980.tb07038.x.
3
The interaction between indomethacin and contractile agents on human isolated airway muscle.吲哚美辛与收缩剂对人离体气道平滑肌的相互作用。
Br J Pharmacol. 1980 Jul;69(3):383-8. doi: 10.1111/j.1476-5381.1980.tb07026.x.
4
Purine receptors in the trachea: is there a receptor for ATP?气管中的嘌呤受体：是否存在ATP受体？
Br J Pharmacol. 1980 Dec;70(4):512-4. doi: 10.1111/j.1476-5381.1980.tb09768.x.
5
Purine antagonists in the identification of adenosine-receptors in guinea-pig trachea and the role of purines in non-adrenergic inhibitory neurotransmission.嘌呤拮抗剂在豚鼠气管腺苷受体鉴定中的作用以及嘌呤在非肾上腺素能抑制性神经传递中的作用。
Br J Pharmacol. 1980 Jul;69(3):359-66. doi: 10.1111/j.1476-5381.1980.tb07022.x.
6
Stimulation of the antigen-induced contraction of guinea-pig trachea and immunological release of histamine and SRS-A from sensitized guinea-pig lung by (2-isopropyl-3-indolyl)-3 pyridyl ketone (L8027) and indomethacin.（2-异丙基-3-吲哚基）-3-吡啶基酮（L8027）和吲哚美辛对豚鼠气管抗原诱导收缩的刺激作用以及对致敏豚鼠肺中组胺和慢反应物质-A的免疫释放作用。
Br J Pharmacol. 1980;71(1):65-73. doi: 10.1111/j.1476-5381.1980.tb10910.x.
7
Specificity of adenosine uptake into the heart and inhibition by dipyridamole.腺苷摄取入心脏的特异性及双嘧达莫对其的抑制作用。
Eur J Pharmacol. 1970 Mar;9(3):265-8. doi: 10.1016/0014-2999(70)90221-9.
8
A non-adrenergic inhibitory nervous pathway in guinea-pig trachea.豚鼠气管中的一条非肾上腺素能抑制性神经通路。
Br J Pharmacol. 1974 Oct;52(2):167-74. doi: 10.1111/j.1476-5381.1974.tb09697.x.
9
Selective inhibitor of slow reacting substance of anaphylaxis.过敏反应迟缓反应物质的选择性抑制剂。
Nat New Biol. 1973 Oct 17;245(146):215-7. doi: 10.1038/newbio245215a0.
10
Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs.化学或机械刺激豚鼠肺诱导兔主动脉收缩物质（RCS）和前列腺素的释放。
Br J Pharmacol. 1973 Oct;49(2):226-42. doi: 10.1111/j.1476-5381.1973.tb08368.x.

前列腺素和血栓素对豚鼠离体气管中腺苷和ATP诱导收缩的作用。

Contribution of prostaglandins and thromboxanes to the adenosine and ATP-induced contraction of guinea-pig isolated trachea.

作者信息

Advenier C, Bidet D, Floch-Saint-Aubin A, Renier A

出版信息

Br J Pharmacol. 1982 Sep;77(1):39-44. doi: 10.1111/j.1476-5381.1982.tb09266.x.

DOI:10.1111/j.1476-5381.1982.tb09266.x
PMID:7126994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044646/
Abstract

1 In in vitro experiments adenosine 5'-triphosphate (ATP) and adenosine were found to exert different effects on the guinea-pig isolated trachea depending on whether the trachea had previously been contracted with acetylcholine (ACh) (6.6 x 10(-6) M) or was at resting tone. 2 ATP and adenosine (10(-5) and 10(-3) M) were equipotent in relaxing the precontracted guinea-pig trachea, since concentrations of 1.09 +/- 0.35 and 0.39 +/- 0.16 mM respectively reduced by 25% the ACh-induced contraction. 3 ATP and adenosine (10(-5) and 10(-4) M) caused a moderate contraction of the guinea-pi trachea under resting tone. This effect was antagonized by inhibitors of cyclo-oxygenase (indomethacin 10(-6) M, aspirin 0.3 x 10(-3) M and 3 x 10(-3) M) and of thromboxane synthetase (nictindole 10(-7) M, imidazole 5 x 10(-5) M), which suggests an indirect mechanism of action with release of arachidonic acid derivatives.

摘要
  1. 在体外实验中，发现5'-三磷酸腺苷（ATP）和腺苷对豚鼠离体气管产生不同的作用，这取决于气管此前是否已被乙酰胆碱（ACh，6.6×10⁻⁶ M）收缩或处于静息张力状态。2. ATP和腺苷（10⁻⁵和10⁻³ M）在舒张预先收缩的豚鼠气管方面具有同等效力，因为分别为1.09±0.35 mM和0.39±0.16 mM的浓度可使ACh诱导的收缩减少25%。3. ATP和腺苷（10⁻⁵和10⁻⁴ M）在静息张力状态下引起豚鼠气管适度收缩。这种作用被环氧化酶抑制剂（吲哚美辛10⁻⁶ M、阿司匹林0.3×10⁻³ M和3×10⁻³ M）和血栓素合成酶抑制剂（尼克吲哚10⁻⁷ M、咪唑5×10⁻⁵ M）所拮抗，这提示其作用机制是通过释放花生四烯酸衍生物的间接机制。