Gona O
Exp Eye Res. 1984 Jun;38(6):647-52. doi: 10.1016/0014-4835(84)90183-0.
Whole mounts of lens epithelia from rats fed on a galactose-rich diet for one, two, three or seven days were examined for morphological alterations. The meridional rows of epithelia from lenses of animals fed on galactose for seven days were found to be grossly disorganized or abnormally elongated. There was some indication that the cells were edematous and that the epithelium had become multilayered. These abnormalities apparently extended into the transitional zone. Evidence of the cytoarchitectural changes was present as early as one day after institution of the 30% galactose diet and progressed steadily over the period of observation. The findings provide support for the hypothesis that loss of meridional row integrity is a phenomenon common to development of most types of cortical cataracts.
对喂食富含半乳糖饮食1天、2天、3天或7天的大鼠晶状体上皮全层进行检查，观察其形态学改变。发现喂食半乳糖7天的动物晶状体上皮的子午线排列严重紊乱或异常伸长。有迹象表明细胞出现水肿，上皮已变为多层。这些异常显然延伸至过渡区。早在给予30%半乳糖饮食1天后就出现了细胞结构变化的证据，并在观察期内持续进展。这些发现支持了以下假说，即子午线排列完整性丧失是大多数类型皮质性白内障发展过程中的常见现象。
