3,5,3'-三碘甲状腺原氨酸对培养的人皮肤成纤维细胞胶原蛋白合成的影响。
Effects of 3,5,3'-triiodothyronine on collagen synthesis by cultured human skin fibroblasts.
作者信息
de Rycker C, Vandalem J L, Hennen G
出版信息
FEBS Lett. 1984 Aug 20;174(1):34-7. doi: 10.1016/0014-5793(84)81072-8.
PMID:6468657
Abstract
Addition of 3,5,3'-triiodothyronine (T3) (10(-9)-10(-7) M) to the media of cultured skin fibroblasts was shown to decrease the amount of newly synthesized soluble proteins, including collagen. Polyacrylamide gel electrophoresis of newly synthesized collagen demonstrated that addition of the hormone did not affect the processing of the molecule.
摘要
向培养的皮肤成纤维细胞培养基中添加3,5,3'-三碘甲状腺原氨酸（T3）（10^-9 - 10^-7 M），结果显示新合成的可溶性蛋白（包括胶原蛋白）的量减少。对新合成的胶原蛋白进行聚丙烯酰胺凝胶电泳表明，添加该激素并不影响分子的加工过程。
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