Miyairi M, Oshio C, Watanabe S, Smith C R, Yousef I M, Phillips M J
Gastroenterology. 1984 Oct;87(4):788-92.
The influence of sodium taurocholate on bile canalicular contractions was examined by time-lapse cinephotomicrography of isolated rat hepatocytes in primary monolayer cultures. Frame-by-frame analyses indicates that as the dose of taurocholate increased, the number of contractions increased in a dose-dependent manner up to 5 microM. Because bile canaliculi are the smallest biliary passages across which bile secretion occurs, and because it is known that taurocholic acid within the dose range used in these studies causes a linear increase in bile secretion, the results suggest that canalicular contractions may be a function of canalicular bile secretion.
通过对原代单层培养的分离大鼠肝细胞进行延时电影显微摄影，研究了牛磺胆酸钠对胆小管收缩的影响。逐帧分析表明，随着牛磺胆酸钠剂量的增加，收缩次数以剂量依赖方式增加，直至5微摩尔。由于胆小管是胆汁分泌所经过的最小胆管通道，并且已知在这些研究中使用的剂量范围内的牛磺胆酸会导致胆汁分泌呈线性增加，因此结果表明胆小管收缩可能是胆小管胆汁分泌的一种功能。
