Kaji K, Miyashita M, Seyama Y, Yamashita S
Nihon Yakurigaku Zasshi. 1984 May;83(5):451-7.
The anti-hyperlipidemic effect of the iodine egg was found to be in the neutral lipid (NL) fraction in its yolk. For the purpose of clarifying the hypolipidemic effect of the iodine-containing NL fraction, the effect of clofibrate (CPIB) was investigated. CPIB was found to lower TC, atherogenic index [(TC-HDL cholesterol)/HDL cholesterol], TG and FFA, but not FC; while NL lowered TC, FC and the atherogenic index, but not TG and FFA. Cholesterol metabolites, probably metabolized in the liver, were examined. Hepatic cholesterol level was increased by NL and CPIB. The ratio of fecal bile acid of the excretion type, lithocholic acid (LCA) to deoxycholic acid (DCA), increased when NL and CPIB were administered, but the hepatic HMG-CoA reductase activity, responsible for the endogenous cholesterol synthesis, was not altered. Thus, the anti-hyperlipidemic mechanism of NL may be the mobilization of peripheral cholesterol to the liver, probably for the disposal by excretion as bile acids.
碘蛋的抗高血脂作用被发现存在于其蛋黄的中性脂质（NL）部分。为了阐明含碘NL部分的降血脂作用，研究了氯贝丁酯（CPIB）的作用。发现CPIB可降低总胆固醇（TC）、致动脉粥样硬化指数[（TC - 高密度脂蛋白胆固醇）/高密度脂蛋白胆固醇]、甘油三酯（TG）和游离脂肪酸（FFA），但不降低游离胆固醇（FC）；而NL可降低TC、FC和致动脉粥样硬化指数，但不降低TG和FFA。对可能在肝脏中代谢的胆固醇代谢产物进行了检测。NL和CPIB均可使肝脏胆固醇水平升高。给予NL和CPIB后，排泄型粪便胆汁酸中石胆酸（LCA）与脱氧胆酸（DCA）的比值升高，但负责内源性胆固醇合成的肝脏HMG - CoA还原酶活性未改变。因此，NL的抗高血脂机制可能是将外周胆固醇转运至肝脏，可能是为了通过胆汁酸排泄进行处理。
