绵羊血清IgA的胆汁转运
Biliary transport of serum IgA in sheep.
作者信息
Scicchitano R, Husband A J, Cripps A W
出版信息
Immunology. 1984 Sep;53(1):121-9.
The existence of a hepato-biliary pump for IgA has been studied in sheep by measuring appearance of radioactivity in bile after simultaneous i.v. injection of IgG2 and homologous dimeric IgA each labelled with either 125I or 131I. These experiments confirm that in sheep, as in rodents, IgA is the predominant immunoglobulin in bile and is selectively transported into bile from serum relative to IgG2. In addition, there is evidence for local production of IgA in bile presumably by plasma cells within the liver and biliary tree.
通过同时静脉注射分别用¹²⁵I或¹³¹I标记的IgG2和同源二聚体IgA后，测量胆汁中放射性的出现情况，在绵羊身上研究了IgA肝-胆泵的存在。这些实验证实，在绵羊中，与啮齿动物一样，IgA是胆汁中的主要免疫球蛋白，相对于IgG2，它从血清中被选择性地转运到胆汁中。此外，有证据表明胆汁中的IgA可能是由肝脏和胆管树内的浆细胞在局部产生的。
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