在粗球孢子菌中鉴定出一种对雌二醇具有高亲和力的结合蛋白和一种对睾酮具有低亲和力的结合蛋白。
Identification of a high-affinity binder for estradiol and a low-affinity binder for testosterone in Coccidioides immitis.
作者信息
Powell B L, Drutz D J
出版信息
Infect Immun. 1984 Sep;45(3):784-6. doi: 10.1128/iai.45.3.784-786.1984.
Abstract
Coccidioides immitis cytosol contains a specific estrogen binder with kinetic characteristics (Kd = 2.1 X 10(-8) to 3.7 X 10(-8) M; n = 0.5 to 1.56 pmol/mg of protein) appropriate for interaction with levels of estrogen encountered during pregnancy. The Kd of a separate androgen binder (ca. 10(-7) M) is probably too low to allow interaction with physiological levels of testosterone.
摘要
粗球孢子菌胞质溶胶含有一种特定的雌激素结合蛋白，其动力学特征（解离常数Kd = 2.1×10⁻⁸至3.7×10⁻⁸ M；结合容量n = 0.5至1.56 pmol/mg蛋白质）适合与孕期所遇雌激素水平相互作用。另一种雄激素结合蛋白的解离常数（约10⁻⁷ M）可能过低，无法与生理水平的睾酮相互作用。
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