霍乱患者对霍乱弧菌可溶性血凝素的血清和肠道抗体反应较弱。
Weak serum and intestinal antibody responses to Vibrio cholerae soluble hemagglutinin in cholera patients.
作者信息
Svennerholm A M, Levine M M, Holmgren J
出版信息
Infect Immun. 1984 Sep;45(3):792-4. doi: 10.1128/iai.45.3.792-794.1984.
Abstract
A soluble hemagglutinin/protease from Vibrio cholerae has been suggested to be a putative virulence factor and protective antigen. However, clinical cholera infection gave rise to detectable serum antibody responses to soluble hemagglutinin in only 2 of 10 Bangladeshi patients or 1 of 17 cholera-infected North American volunteers. A gut mucosal immunoglobulin A antibody response to soluble hemagglutinin was seen in 4 of 8 Bangladeshi patients, but in 0 of 10 North American volunteers. These responses were much weaker than those to cholera toxin or lipopolysaccharide.
摘要
霍乱弧菌的一种可溶性血凝素/蛋白酶被认为是一种假定的毒力因子和保护性抗原。然而，在10名孟加拉国患者中，只有2人，或17名感染霍乱的北美志愿者中只有1人，临床霍乱感染产生了可检测到的针对可溶性血凝素的血清抗体反应。8名孟加拉国患者中有4人出现了针对可溶性血凝素的肠道黏膜免疫球蛋白A抗体反应，但10名北美志愿者中无人出现。这些反应比针对霍乱毒素或脂多糖的反应弱得多。
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