霍乱弧菌血凝素/凝集素/蛋白酶可水解纤连蛋白和卵类粘蛋白：重温F.M. 伯内特的研究
Vibrio cholerae hemagglutinin/lectin/protease hydrolyzes fibronectin and ovomucin: F.M. Burnet revisited.
作者信息
Finkelstein R A, Boesman-Finkelstein M, Holt P
出版信息
Proc Natl Acad Sci U S A. 1983 Feb;80(4):1092-5. doi: 10.1073/pnas.80.4.1092.
Abstract
Cholera vibrios produce a single polymeric protein that (i) causes hemagglutination; (ii) appears to participate in their attachment to gut epithelium; (iii) may mediate their detachment from gut epithelium; and (iv) is a protease that hydrolyzes fibronectin and mucin, cleaves lactoferrin, and nicks the A subunit of the choleragen-related heat-labile enterotoxin of Escherichia coli.
摘要
霍乱弧菌产生一种单一的聚合蛋白，该蛋白：（i）引起血细胞凝集；（ii）似乎参与其与肠道上皮的附着；（iii）可能介导其从肠道上皮脱离；以及（iv）是一种蛋白酶，可水解纤连蛋白和粘蛋白，裂解乳铁蛋白，并切割大肠杆菌霍乱毒素相关热不稳定肠毒素的A亚基。
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