Jackson A C, Watson J W, Kotlikoff M I
J Appl Physiol Respir Environ Exerc Physiol. 1984 Jul;57(1):34-9. doi: 10.1152/jappl.1984.57.1.34.
We measured impedances of the respiratory system (Zrs) and lung (ZL) in anesthetized and paralyzed dogs at frequencies between 4 and 64 Hz. Zrs was measured at functional residual capacity (FRC) and with mean transpulmonary pressures (Ptp) of 12 and 30 cmH2O; ZL was measured with the chest wall open at FRC and Ptp = 12 cmH2O. From these data we derived chest wall impedances at FRC and 12 cmH2O. Effective resistances of the respiratory system, lung, and chest wall were all frequency dependent. At frequencies below 22 Hz frequency dependence of respiratory system resistance was due to the frequency dependence of the chest wall, whereas at higher frequencies it was due to frequency dependence of the lung. Analysis of the impedance data between 4 and 32 Hz provided estimates of resistance, inertance, and compliance of the lung, chest wall, and respiratory system. At FRC, 41% of the respiratory system resistance was due to the lung and 59% was associated with the chest wall. Nearly all of the respiratory inertance (98%) was due to the lung. Lung compliance was approximately twice that of the chest wall, the former accounting for approximately one-third of respiratory elasticity. As lung volume was increased, respiratory resistance and compliance decreased; inertance also decreased, although this change was not significant.
我们在4至64赫兹的频率范围内，对麻醉和麻痹状态下的狗的呼吸系统阻抗（Zrs）和肺阻抗（ZL）进行了测量。Zrs在功能残气量（FRC）以及平均跨肺压（Ptp）为12和30厘米水柱时进行测量；ZL在FRC且胸壁开放、Ptp = 12厘米水柱时进行测量。根据这些数据，我们得出了FRC和12厘米水柱时的胸壁阻抗。呼吸系统、肺和胸壁的有效电阻均与频率有关。在22赫兹以下的频率，呼吸系统电阻的频率依赖性归因于胸壁的频率依赖性，而在较高频率时，则归因于肺的频率依赖性。对4至32赫兹之间的阻抗数据进行分析，得出了肺、胸壁和呼吸系统的电阻、惯性和顺应性的估计值。在FRC时，呼吸系统电阻的41%归因于肺，59%与胸壁有关。几乎所有的呼吸惯性（98%）都归因于肺。肺顺应性约为胸壁顺应性的两倍，前者约占呼吸弹性的三分之一。随着肺容积增加，呼吸电阻和顺应性降低；惯性也降低，尽管这种变化不显著。
