Hantos Z, Daróczy B, Suki B, Galgóczy G, Csendes T
J Appl Physiol (1985). 1986 Jan;60(1):123-32. doi: 10.1152/jappl.1986.60.1.123.
Respiratory mechanical impedances were determined during voluntary apnea in five healthy subjects, by means of 0.25- to 5-Hz pseudo/random oscillations applied at the mouth. The total respiratory impedance was partitioned into pulmonary (ZL) and chest wall components with the esophageal balloon technique; corrections were made for the upper airway shunt impedance and the compressibility of alveolar gas. Neglect of these shunt effects did not qualitatively alter the frequency dependence of impedances but led to underestimations in impedance, especially in the chest wall resistance (Rw), which decreased by 20-30% at higher frequencies. The total resistance (Rrs) was markedly frequency dependent, falling from 0.47 +/- 0.06 (SD) at 0.25 Hz to 0.17 +/- 0.01 at 1 Hz and 0.15 +/- 0.01 kPa X l-1 X s at 5 Hz. The changes in Rrs were caused by the frequency dependence of Rw almost exclusively between 0.25 and 2 Hz and in most part between 2 and 5 Hz. The effective total respiratory (Crs,e) and pulmonary compliance were computed with corrections for pulmonary inertance derived from three- and five-parameter model fittings of ZL. Crs,e decreased from the static value (1.03 +/- 0.18 l X kPa-1) to a level of approximately 0.35 l X kPa-1 at 2-3 Hz; this change was primarily caused by the frequency-dependent behavior of chest wall compliance.
通过在口腔施加0.25至5赫兹的伪随机振荡，对五名健康受试者在自主呼吸暂停期间的呼吸机械阻抗进行了测定。采用食管气囊技术将总呼吸阻抗分为肺阻抗（ZL）和胸壁阻抗两部分；对上气道分流阻抗和肺泡气体可压缩性进行了校正。忽略这些分流效应并没有定性地改变阻抗的频率依赖性，但导致了阻抗的低估，尤其是胸壁阻力（Rw），在较高频率下降低了20%-30%。总阻力（Rrs）明显依赖于频率，从0.25赫兹时的0.47±0.06（标准差）降至1赫兹时的0.17±0.01以及5赫兹时的0.15±0.01千帕·升-1·秒。Rrs的变化几乎完全是由0.25至2赫兹之间以及大部分由2至5赫兹之间的Rw频率依赖性引起的。通过对ZL进行三参数和五参数模型拟合得出的肺惯性校正，计算出了有效总呼吸顺应性（Crs,e）和肺顺应性。Crs,e从静态值（1.03±0.18升·千帕-1）降至2至3赫兹时约0.35升·千帕-1的水平；这种变化主要是由胸壁顺应性的频率依赖性行为引起的。
