Löhrke H, Hesse B, Goerttler K
J Cancer Res Clin Oncol. 1984;108(2):192-6. doi: 10.1007/BF00402466.
A group of 150 female NMRI mice of the outbred stock Sut:NMRT was kept until they died naturally, at which time they were necropsied and examined histologically for spontaneous tumors. The natural life expectancy (median) was 782 days. Life expectancy was markedly reduced by mammary and pulmonary adenocarcinoma, and by tumors of the hypophysis. The spontaneous tumor rate was 58%. That is to say, 87 of the 150 mice had spontaneous tumors: 57 animals each had one tumor, 20 animals each had two tumors, and 10 animals each had three tumors. The organs most commonly affected by tumors were those of the lymphoreticular and haematopoietic systems, followed by the respiratory tract in second place and the breast in third place. Data reported in the literature generally show the same organ distribution, but the total tumor rate given is generally somewhat lower as the animals are seldom left alive until they die naturally (spontaneously).
一组150只远交系Sut:NMRT的雌性NMRI小鼠饲养至自然死亡，此时对它们进行尸检并进行组织学检查以查找自发肿瘤。自然预期寿命（中位数）为782天。预期寿命因乳腺和肺腺癌以及垂体肿瘤而显著缩短。自发肿瘤发生率为58%。也就是说，150只小鼠中有87只患有自发肿瘤：57只动物各有一个肿瘤，20只动物各有两个肿瘤，10只动物各有三个肿瘤。最常受肿瘤影响的器官是淋巴网状和造血系统的器官，其次是呼吸道，第三位是乳腺。文献报道的数据通常显示相同的器官分布，但给出的总肿瘤发生率通常略低，因为动物很少存活至自然（自发）死亡。
