Cullen P R, Brownlie J, Kimberlin R H
J Comp Pathol. 1984 Jul;94(3):405-15. doi: 10.1016/0021-9975(84)90027-6.
The frequencies of 15 lymphocyte antigens were determined in 2 experimental flocks of Herdwick sheep derived from the same foundation stock. The Blue Flock had been bred for resistance, and the Red flock for susceptibility, to a standard dose of the SSBP/1 source of scrapie injected subcutaneously. Although there were marked frequently differences between the 158 Red flock and 51 Blue flock sheep tested these differences could be attributed to genetic drift. Within the Red flock no significant frequency differences were observed between 16 sheep which developed natural scrapie and their healthy flockmates. All Red flock lambs born in 1980 were injected subcutaneously with SSBP/1 scrapie; there was no difference in antigen frequency between the group which subsequently developed experimental scrapie (30) and the group which did not (21). The segregation of antigen haplotypes in the Red flock pedigrees showed no evidence of MHC linkage with either natural or experimental scrapie.
在源自同一基础种群的两群赫德威克绵羊的实验群体中，测定了15种淋巴细胞抗原的频率。蓝群羊经过选育具有对皮下注射标准剂量的SSBP/1羊瘙痒病病原体的抗性，而红群羊则选育为易感群体。尽管在接受检测的158只红群羊和51只蓝群羊之间存在明显的频率差异，但这些差异可归因于遗传漂变。在红群羊中，16只患自然型羊瘙痒病的羊与其健康的同群羊之间未观察到显著的频率差异。1980年出生的所有红群羊羔羊均皮下注射了SSBP/1羊瘙痒病病原体；随后发生实验性羊瘙痒病的组（30只）和未发生该病的组（21只）之间的抗原频率没有差异。红群羊系谱中抗原单倍型的分离情况表明，没有证据显示主要组织相容性复合体（MHC）与自然型或实验性羊瘙痒病存在连锁关系。
