Millot P, Chatelain J, Cathala F
Immunogenetics. 1985;21(2):117-23. doi: 10.1007/BF00364863.
Gene frequencies of 13 sheep lymphocyte factors (11 factors controlled by the sheep OLA complex including three closely linked loci, and two factors by two minor loci) were compared in 189 sheep of two breeds: a. infected with scrapie, b. healthy in a contaminated environment, and c., normal. In a and c, OLA gene frequencies were similar. In healthy sheep in a contaminated environment (b), some OLA gene frequencies were higher in one breed and lower in the other. In each breed, three antigens had their frequencies significantly modified; two of them were the same in the two breeds, but they showed an inverse variation. Thus, the relative risk of clinical scrapie decreased in one breed and increased in the other for the same OLA gene. These data indicate first, that OLA antigens are not directly involved in causing scrapie, and second, that the OLA complex is linked to at least one scrapie resistance/susceptibility locus. In practice, it should be possible to select more resistent sheep, using some OLA antigens but an investigation of the OLA genes and the resistance to scrapie in a given breed is necessary before the selection.
在两个品种的189只绵羊中比较了13种绵羊淋巴细胞因子的基因频率（11种因子由绵羊OLA复合体控制，包括三个紧密连锁的基因座，另外两种因子由两个次要基因座控制）：a. 感染羊瘙痒病的；b. 在受污染环境中健康的；c. 正常的。在a组和c组中，OLA基因频率相似。在受污染环境中健康的绵羊（b组）中，某些OLA基因频率在一个品种中较高，而在另一个品种中较低。在每个品种中，三种抗原的频率有显著改变；其中两种在两个品种中相同，但呈现相反的变化。因此，对于相同的OLA基因，临床羊瘙痒病的相对风险在一个品种中降低，而在另一个品种中增加。这些数据首先表明，OLA抗原不直接参与羊瘙痒病的发生，其次表明OLA复合体与至少一个羊瘙痒病抗性/易感性基因座相连。在实践中，利用某些OLA抗原选择更具抗性的绵羊应该是可行的，但在进行选择之前，有必要对特定品种的OLA基因和对羊瘙痒病的抗性进行调查。
