Hayes D L, Holmes D R, Vlietstra R E, Osborn M J
J Am Coll Cardiol. 1984 Sep;4(3):556-9. doi: 10.1016/s0735-1097(84)80101-1.
Dual chamber (DDD) or "universal" pacemakers have had a significant impact on the advancement of artificial pacemakers by providing a more physiologic approach to cardiac pacing. However, with the early generation of DDD pacemakers (pacemakers that sense and pace in both the atrium and the ventricle), a significant number of patients experienced pacemaker-mediated tachycardia because intact ventriculoatrial conduction was sensed in the atrium and a reentrant tachycardia was induced. Newer generation DDD pacemakers have provided longer atrial refractory periods, which should correct this problem. In this study the first and second years of a 2 year experience with DDD pacemakers were compared to determine if the newer generation devices have allowed maintenance of pacing in the DDD mode as opposed to reprogramming to some alternate mode because of pacemaker-mediated tachycardia or other pacing problems. The results showed a significant decrease in pacemaker-mediated tachycardia during the second year and continuation of pacing in the DDD mode in a higher percent of patients. This improvement is attributed to improvement in the pulse generator as well as better patient selection.
双腔(DDD)或“通用”起搏器通过提供更符合生理的心脏起搏方式,对人工起搏器的发展产生了重大影响。然而,早期的DDD起搏器(能感知心房和心室并进行起搏的起搏器)使大量患者出现起搏器介导的心动过速,原因是心房感知到完整的室房传导并诱发了折返性心动过速。新一代DDD起搏器延长了心房不应期,有望纠正这一问题。在本研究中,对使用DDD起搏器两年中的第一年和第二年进行了比较,以确定新一代设备是否能维持DDD模式起搏,而非因起搏器介导的心动过速或其他起搏问题而重新编程为某种替代模式。结果显示,第二年起搏器介导的心动过速显著减少,且更高比例的患者能够继续以DDD模式起搏。这一改善归因于脉冲发生器的改进以及更好的患者选择。