Gallagher C H, Canfield P J, Greenoak G E, Reeve V E
J Invest Dermatol. 1984 Sep;83(3):169-74. doi: 10.1111/1523-1747.ep12263512.
Tumors were induced in the HRA/Skh-1 hairless mouse by repeated irradiations of minimally erythemal and suberythemal doses of UV radiation. Aspects of tumor induction were recorded using a combined system of mapping and gross descriptive classification. Tumors of epithelial and dermal (mesenchymal) origin were confirmed histologically and their types correlated well with those reported by earlier investigators. Among those classified, however, appendage tumors and hemangiomas have rarely been described. The progression to malignancy of epithelial tumors was systematically characterized and was a consistent histogenic feature in our experiments. Squamous cell carcinomas represented a final stage for development arising ab initio or from other forms, in particular papillomas which commonly passed through intermediate forms toward definite malignancy. While confirming previous studies of UV-induced tumors, this report extends our knowledge of their dynamics as this bears upon any experimental objective which includes an assessment of tumorigenicity.
通过重复照射最小红斑剂量和亚红斑剂量的紫外线，在HRA/Skh-1无毛小鼠中诱发肿瘤。使用绘图和大体描述性分类相结合的系统记录肿瘤诱导的各个方面。上皮和真皮（间充质）起源的肿瘤经组织学证实，其类型与早期研究者报道的类型高度相关。然而，在分类的肿瘤中，附属器肿瘤和血管瘤很少被描述。上皮肿瘤向恶性的进展得到了系统的表征，并且是我们实验中一致的组织发生特征。鳞状细胞癌代表了从头发生或从其他形式，特别是乳头状瘤发展而来的最终阶段，乳头状瘤通常会通过中间形式发展为明确的恶性肿瘤。在证实先前关于紫外线诱导肿瘤的研究的同时，本报告扩展了我们对其动态的认识，因为这与任何包括评估致瘤性的实验目标相关。
