Ohmann H B, Gilchrist J E, Babiuk L A
J Gen Virol. 1984 Sep;65 ( Pt 9):1487-95. doi: 10.1099/0022-1317-65-9-1487.
Treatment of bovine alveolar macrophages (BAM) with bovine leukocyte interferon (BoIFN-alpha 1) resulted in reduced bovine herpesvirus type 1 replication and spread. This was demonstrated by reduced virus yields and number of cells infected. BoIFN-alpha 1 treatment of BAM also induced enhanced Fc receptor expression and/or avidity by the cells, increased their activity in antibody-dependent cellular cytotoxicity, and augmented their extrinsic antiviral activity as measured by a reduction in the development of plaques in a susceptible cell line. These results are discussed in the context of the possible role of interferon in activation of AM during the early phases of a virus infection.
用牛白细胞干扰素（BoIFN-α1）处理牛肺泡巨噬细胞（BAM）可导致牛1型疱疹病毒的复制和传播减少。这通过病毒产量降低和受感染细胞数量减少得以证明。用BoIFN-α1处理BAM还可诱导细胞增强Fc受体表达和/或亲和力，增加其在抗体依赖性细胞毒性中的活性，并通过减少易感细胞系中噬斑的形成来增强其外在抗病毒活性。本文在干扰素可能在病毒感染早期激活肺泡巨噬细胞过程中所起作用的背景下对这些结果进行了讨论。
