Babiuk L A, Lawman M J, Gifford G A
Antimicrob Agents Chemother. 1987 May;31(5):752-7. doi: 10.1128/AAC.31.5.752.
Intranasal or intramuscular treatment of calves with recombinant bovine alpha 1 interferon before challenge with bovine herpesvirus type 1 and Pasteurella haemolytica reduced clinical signs, number of sick days, lung lesions, and weight loss. The effective dose was determined to be relatively broad within the range of 1 to 50 mg per animal. No adverse effects were observed even at high doses of interferon (50 mg per animal). Administration before virus infection was more effective than administration at the same time as virus infection. Although interferon administration had dramatic effects on the survival of animals, it did not have much effect on virus secretion in the upper respiratory tract. Therefore, the mechanism by which interferon reduces the susceptibility of animals to viral-bacterial synergy was postulated to be via its immunomodulatory effects.
在小牛受到1型牛疱疹病毒和溶血巴斯德氏菌攻击之前，通过鼻内或肌肉注射重组牛α1干扰素进行治疗，可减少临床症状、患病天数、肺部病变和体重减轻。确定有效剂量在每只动物1至50毫克的范围内相对较宽。即使在高剂量干扰素（每只动物50毫克）下也未观察到不良反应。病毒感染前给药比病毒感染时同时给药更有效。尽管干扰素给药对动物存活有显著影响，但对其在上呼吸道的病毒分泌影响不大。因此，推测干扰素降低动物对病毒 - 细菌协同作用易感性的机制是通过其免疫调节作用。
