一种用于证明镇痛药对人体中枢作用的新方法。
A new method for demonstration of central effects of analgesic agents in man.
作者信息
Torebjörk H E, Schady W, Ochoa J L
出版信息
J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):862-9. doi: 10.1136/jnnp.47.8.862.
Abstract
A new method of eliciting experimental pain in man is described. Microelectrodes are inserted percutaneously into the peripheral nerves of awake subjects, and are positioned close to nociceptive fibres in order to elicit pain during intraneural electrical stimulation. Under fixed stimulation conditions the estimated magnitude of evoked pain remains relatively stable, unless a high stimulus frequency is used, which may lead to excitation failure of nociceptive fibres. This method can be employed to test for possible central modulation of pain, for instance by analgesic agents, since peripheral receptors are bypassed.
摘要
本文描述了一种在人体诱发实验性疼痛的新方法。将微电极经皮插入清醒受试者的外周神经，并放置在靠近伤害性纤维的位置，以便在神经内电刺激期间诱发疼痛。在固定的刺激条件下，诱发疼痛的估计强度保持相对稳定，除非使用高刺激频率，这可能导致伤害性纤维的兴奋失败。由于绕过了外周感受器，该方法可用于测试疼痛可能的中枢调节，例如通过镇痛剂进行调节。
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