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抗半乳糖脑苷脂血清在体内使视神经脱髓鞘。

Antigalactocerebroside serum demyelinates optic nerve in vivo.

作者信息

Sergott R C, Brown M J, Silberberg D H, Lisak R P

出版信息

J Neurol Sci. 1984 Jun;64(3):297-303. doi: 10.1016/0022-510x(84)90177-1.

DOI:10.1016/0022-510x(84)90177-1
PMID:6470740
Abstract

Antiserum to the myelin lipid galactocerebroside (GalC) causes rapidly progressive focal demyelination when injected into guinea pig optic nerves. The capacity of anti-GalC to induce central nervous system demyelination is complement-dependent, and demyelinating activity is present in the immunoglobulin fraction of anti-GalC serum. Demyelination appears to result from primary damage to oligodendrocytes.

摘要

将抗髓磷脂脂质半乳糖脑苷脂（GalC）的抗血清注入豚鼠视神经时，会导致快速进展的局灶性脱髓鞘。抗GalC诱导中枢神经系统脱髓鞘的能力是补体依赖性的，并且脱髓鞘活性存在于抗GalC血清的免疫球蛋白部分。脱髓鞘似乎是由少突胶质细胞的原发性损伤引起的。

相似文献

1
Antigalactocerebroside serum demyelinates optic nerve in vivo.抗半乳糖脑苷脂血清在体内使视神经脱髓鞘。
J Neurol Sci. 1984 Jun;64(3):297-303. doi: 10.1016/0022-510x(84)90177-1.
2
Antiserum induced myelination inhibition in vitro without complement.抗血清在无补体情况下可在体外诱导髓鞘形成抑制。
Brain Res. 1979 Nov 9;177(1):105-14. doi: 10.1016/0006-8993(79)90921-1.
3
Galactocerebroside antiserum causes demyelination of cat optic nerve.半乳糖脑苷脂抗血清会导致猫视神经脱髓鞘。
Brain Res. 1985 Mar 25;330(2):378-81. doi: 10.1016/0006-8993(85)90702-4.
4
Demyelination in vitro. Absorption studies demonstrate that galactocerebroside is a major target.体外脱髓鞘。吸收研究表明半乳糖脑苷脂是主要靶点。
J Neurol Sci. 1981 Oct;52(1):117-31. doi: 10.1016/0022-510x(81)90140-4.
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Effect of antiglycolipid antisera on the lipid composition of cultured mouse spinal cords.抗糖脂抗血清对培养的小鼠脊髓脂质成分的影响。
Exp Neurol. 1986 Jun;92(3):752-6. doi: 10.1016/0014-4886(86)90314-6.
6
Experimental demyelinating optic neuropathy induced by intra-neural injection of galactocerebroside antiserum.
J Neurol Sci. 1984 Aug;65(2):125-35. doi: 10.1016/0022-510x(84)90077-7.
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EAE, EAN and galactocerebroside sera bind to oligodendrocytes and Schwann cells.实验性自身免疫性脑脊髓炎、实验性变态反应性神经炎血清与少突胶质细胞和雪旺氏细胞结合。
J Neurol Sci. 1980 Nov;48(2):287-96. doi: 10.1016/0022-510x(80)90207-5.
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[Antibodies to myelin cerebrosides and their role in the pathogenesis of autoimmune demyelinating diseases (review)].[抗髓磷脂脑苷脂抗体及其在自身免疫性脱髓鞘疾病发病机制中的作用（综述）]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(12):1863-72.
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In vivo CNS demyelination mediated by anti-galactocerebroside antibody.抗半乳糖脑苷脂抗体介导的体内中枢神经系统脱髓鞘。
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Antibodies to galactocerebroside bind to oligodendroglia in suspension culture.抗半乳糖脑苷脂抗体与悬浮培养中的少突胶质细胞结合。
J Neurol Sci. 1979 Jan;40(1):65-73. doi: 10.1016/0022-510x(79)90009-1.

引用本文的文献

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Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions.实验性变应性脑脊髓炎：致脑炎性T淋巴细胞与脱髓鞘抗体之间的平衡决定了脱髓鞘病变的大小和结构。
Acta Neuropathol. 1988;75(6):566-76. doi: 10.1007/BF00686201.
2
Oligodendrocytes and oligodendrocyte/type-2 astrocyte progenitor cells of adult rats are specifically susceptible to the lytic effects of complement in absence of antibody.成年大鼠的少突胶质细胞和少突胶质细胞/2型星形胶质细胞祖细胞在没有抗体的情况下对补体的溶解作用特别敏感。
Proc Natl Acad Sci U S A. 1989 Nov;86(22):9025-9. doi: 10.1073/pnas.86.22.9025.
3
In vivo CNS demyelination mediated by anti-galactocerebroside antibody.
抗半乳糖脑苷脂抗体介导的体内中枢神经系统脱髓鞘。
Acta Neuropathol. 1989;77(6):621-8. doi: 10.1007/BF00687890.
4
MS as autoimmune disease: myelin antigens.多发性硬化症作为自身免疫性疾病：髓鞘抗原
Res Immunol. 1989 Feb;140(2):181-7; discussion 245-8. doi: 10.1016/0923-2494(89)90083-7.
5
Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.针对髓鞘/少突胶质细胞糖蛋白的循环小鼠单克隆抗体增强大鼠急性变应性脑脊髓炎中的脱髓鞘作用
Am J Pathol. 1988 Mar;130(3):443-54.
6
Neuropsychiatric manifestations of systemic lupus erythematosus: the value of anticardiolipin, antigangliosides and antigalactocerebrosides antibodies.系统性红斑狼疮的神经精神表现：抗心磷脂、抗神经节苷脂和抗半乳糖脑苷脂抗体的价值
Clin Rheumatol. 1990 Dec;9(4):489-97. doi: 10.1007/BF02030510.
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Optic nerve sheath decompression: neuropathologic, clinical, and hemodynamic results and rationale.视神经鞘减压术：神经病理学、临床及血流动力学结果与原理
Trans Am Ophthalmol Soc. 1991;89:675-720.
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Monoclonal antibody to Theiler's murine encephalomyelitis virus defines a determinant on myelin and oligodendrocytes, and augments demyelination in experimental allergic encephalomyelitis.针对泰勒氏鼠脑脊髓炎病毒的单克隆抗体可确定髓鞘和少突胶质细胞上的一个决定簇，并加剧实验性过敏性脑脊髓炎中的脱髓鞘病变。
J Exp Med. 1990 Jun 1;171(6):1893-907. doi: 10.1084/jem.171.6.1893.
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Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord.抑制髓鞘形成的起始可延长胚胎脊髓功能修复的许可期。
Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11664-8. doi: 10.1073/pnas.89.24.11664.