Carroll W M, Jennings A R, Mastaglia F L
Brain Res. 1985 Mar 25;330(2):378-81. doi: 10.1016/0006-8993(85)90702-4.
A model of immune-mediated optic nerve demyelination is described. Micro-injection of small volumes (less than 5 microliter) of high titer polyclonal anti-Gal-C serum into the cat optic nerve resulted in a focal, highly selective demyelinative lesion followed by remyelination. Demyelination appears to be due to a dual effect on myelin and on oligodendrocytes. The numbers of these cells within the lesion were initially reduced but subsequently increased as remyelination occurred.
本文描述了一种免疫介导的视神经脱髓鞘模型。将少量（小于5微升）高滴度的多克隆抗半乳糖脑苷脂（Gal-C）血清显微注射到猫的视神经中，会导致局灶性、高度选择性的脱髓鞘病变，随后发生髓鞘再生。脱髓鞘似乎是由于对髓鞘和少突胶质细胞的双重作用所致。病变区内这些细胞的数量最初减少，但随着髓鞘再生的发生，随后又增加。
