Ljungberg O
Med Hypotheses. 1984 Jul;14(3):253-7. doi: 10.1016/0306-9877(87)90125-3.
Follicular and papillary thyroid carcinoma have for many years been regarded as biologically distinct from medullary thyroid carcinoma. The recent recognition of a tumor type which is morphologically and functionally intermediate between these two categories suggests however that differentiated thyroid carcinoma may be regarded as a continuous spectrum of tumor types all of which are derived from a common thyroid stem cell, capable of developing both follicular and parafollicular tumor cells, as well as intermediate cell forms. It is also proposed that anaplastic giant cell thyroid carcinoma represents a heterogeneous group consisting of the anaplastic counterparts not only to follicular and papillary carcinoma but also to the intermediate type and to classical medullary carcinoma.
多年来，滤泡状和乳头状甲状腺癌在生物学上一直被认为与髓样甲状腺癌不同。然而，最近发现了一种在形态和功能上介于这两类之间的肿瘤类型，这表明分化型甲状腺癌可能被视为一系列连续的肿瘤类型，所有这些类型均源自共同的甲状腺干细胞，能够产生滤泡状和滤泡旁肿瘤细胞以及中间细胞形式。还提出，间变性巨细胞甲状腺癌是一个异质性群体，不仅包括滤泡状癌和乳头状癌的间变性对应物，还包括中间型和经典髓样癌的间变性对应物。
