King R G
Med Hypotheses. 1984 Jul;14(3):301-6. doi: 10.1016/0306-9877(87)90133-2.
Raised aluminium levels have been found in brains of patients with Alzheimer's dementia (1,2), a disease in which reductions have been reported in various parameters of presynaptic cholinergic nerve function, including choline uptake, acetylcholine synthesis and choline acetyltransferase activity (3). Aluminium has been found to inhibit choline transport by isolated rat brain nerve endings (4) and human erythrocytes (5), and also to cause an encephalopathy in rabbits with neurofibrillary tangles and reduced neuronal choline acetyltransferase activity (6). It is therefore hypothesised that raised brain aluminium levels in Alzheimer's dementia may contribute to the cholinergic neuronal deficits in this disease. If this is the case, then aluminium chelating agents may be of value in its treatment.
在阿尔茨海默病性痴呆患者的大脑中发现铝含量升高(1,2)，据报道，在这种疾病中，包括胆碱摄取、乙酰胆碱合成和胆碱乙酰转移酶活性在内的突触前胆碱能神经功能的各种参数均有所降低(3)。已发现铝可抑制离体大鼠脑神经根(4)和人红细胞(5)的胆碱转运，还可导致兔出现神经原纤维缠结和神经元胆碱乙酰转移酶活性降低的脑病(6)。因此，有人推测，阿尔茨海默病性痴呆患者大脑铝含量升高可能导致该疾病中的胆碱能神经元缺陷。如果是这样，那么铝螯合剂可能对其治疗有价值。
