Kemp R
Med J Aust. 1984 Sep 29;141(7):437-42. doi: 10.5694/j.1326-5377.1984.tb132856.x.
The cephalosporins are a group of antibiotic agents that have been available now for 20 years. Three classes, or generations, of cephalosporins are recognized. The newer third-generation drugs have wider spectra of antibacterial activity; because of this attribute and their ability to achieve high bactericidal titres in CSF these newer compounds constitute an advance in antibiotic therapy by providing safe and effective treatment for Gram-negative bacillary meningitis. The earlier cephalosporins provide cheap, useful and convenient prophylaxis for vascular and orthopaedic operations near the inguinal area. Comparative trials with other broad-spectrum agents need to be performed before the true place of the third-generation agents in anti-infective therapy and prophylaxis is finally determined.
头孢菌素是一类现已问世20年的抗生素。目前已确认有三类，即三代头孢菌素。较新的第三代药物具有更广泛的抗菌活性谱；由于这一特性以及它们在脑脊液中能达到高杀菌效价的能力，这些较新的化合物通过为革兰氏阴性杆菌性脑膜炎提供安全有效的治疗，在抗生素治疗方面取得了进展。早期的头孢菌素为腹股沟附近的血管和骨科手术提供了廉价、有用且方便的预防措施。在最终确定第三代药物在抗感染治疗和预防中的真正地位之前，需要与其他广谱药物进行对比试验。
