Fitzgerald R H
Orthop Clin North Am. 1984 Jul;15(3):537-46.
Antibiotics are able to penetrate normal and osteomyelitic bone in a fashion that permits concentrations equivalent to those found in the serum following intravenous administration. There is no osseous barrier or gradient in osseous tissue to antibiotic penetration.
抗生素能够以一种使其在骨组织中的浓度等同于静脉给药后血清中浓度的方式穿透正常骨和骨髓炎骨。骨组织对抗生素的穿透不存在骨屏障或浓度梯度。
