Redding G J, McMurtry I, Reeves J T
Pediatr Res. 1984 Jul;18(7):579-83. doi: 10.1203/00006450-198407000-00002.
We administered sodium meclofenamate, a prostaglandin synthetase inhibitor, to 15 piglets (ages 5-70 d) to test the hypothesis that endogenous prostaglandin pulmonary vasodilators influence total pulmonary resistance under both normoxic and hypoxic conditions. No significant differences in hemodynamic measurements were found between the control group and drug-treated animals more than 12-d-old. When six experimental animals less than 12 d of age were compared with six age-matched controls, meclofenamate produced a small but significant increase in mean pulmonary artery pressure (110 +/- 9 versus 97 +/- 10%, P less than 0.05) and total pulmonary resistance (135 +/- 23 versus 102 +/- 12%, P less than 0.03). The magnitude of the change in total pulmonary resistance produced by 2 mg/kg of meclofenamate during normoxia correlated inversely with postnatal age (r = 0.83, P less than 0.01). Individual changes in pulmonary hemodynamics produced by acute hypoxia after meclofenamate treatment were the same as pretreatment values and were similar in both young and older animals.
我们给15头仔猪（年龄5 - 70天）注射了氯灭酸（一种前列腺素合成酶抑制剂），以检验内源性前列腺素肺血管舒张剂在常氧和低氧条件下影响总肺阻力这一假设。在12日龄以上的对照组动物和药物治疗动物之间，血流动力学测量未发现显著差异。当将6只小于12日龄的实验动物与6只年龄匹配的对照动物进行比较时，氯灭酸使平均肺动脉压出现了虽小但显著的升高（分别为110±9%和97±10%，P<0.05），并且使总肺阻力升高（分别为135±23%和102±12%，P<0.03）。在常氧条件下，2mg/kg氯灭酸引起的总肺阻力变化幅度与出生后年龄呈负相关（r = 0.83，P<0.01）。氯灭酸治疗后急性低氧引起的肺血流动力学个体变化与治疗前值相同，并且在幼龄和老龄动物中相似。
