Konstam M A, Hill N S, Bonin J D, Isner J M
Exp Lung Res. 1987;12(4):331-45. doi: 10.3109/01902148709062844.
The effect of the cyclooxygenase inhibitors ibuprofen and meclofenamate were studied to assess the role of prostaglandin release in mediating the hemodynamic response to acute pulmonary microembolism in awake rabbits. In Group I (n = 10), a control group receiving only saline infusion, there was no change in pulmonary artery pressure, thermodilution cardiac output, or pulmonary vascular resistance. Group II (n = 12) received sequential intravenous doses of polyacrylamide microspheres averaging 34 mu in diameter, and demonstrated a progressive decrease in cardiac output and stroke volume and increases in pulmonary artery pressure and pulmonary vascular resistance. Pretreatment with either ibuprofen (Group III; n = 10) or meclofenamate (Group IV; n = 9) resulted in no change in resting hemodynamics and only minimally altered the effect of microembolism on pulmonary artery pressure. However, both ibuprofen and meclofenamate abolished the microembolism-induced decrease in cardiac output and stroke volume and blunted the increases in pulmonary artery pressure and pulmonary vascular resistance. The hemodynamic consequences of pulmonary microembolism in awake rabbits, particularly the decrease in cardiac output, are partly mediated by prostaglandin release, which alters pulmonary vascular tone and/or myocardial function.
研究了环氧化酶抑制剂布洛芬和甲氯芬那酸的作用，以评估前列腺素释放在介导清醒家兔对急性肺微栓塞的血流动力学反应中的作用。在第一组（n = 10）中，即仅接受生理盐水输注的对照组，肺动脉压、热稀释心输出量或肺血管阻力均无变化。第二组（n = 12）接受了平均直径为34微米的聚丙烯酰胺微球的连续静脉注射，结果显示心输出量和每搏输出量逐渐下降，肺动脉压和肺血管阻力增加。布洛芬预处理（第三组；n = 10）或甲氯芬那酸预处理（第四组；n = 9）导致静息血流动力学无变化，且仅轻微改变微栓塞对肺动脉压的影响。然而，布洛芬和甲氯芬那酸均消除了微栓塞引起的心输出量和每搏输出量的下降，并减弱了肺动脉压和肺血管阻力的增加。清醒家兔肺微栓塞的血流动力学后果，尤其是心输出量的下降，部分是由前列腺素释放介导的，前列腺素释放会改变肺血管张力和/或心肌功能。
