血管活性肠肽对豚鼠结肠带的作用需要完整序列。

The effect of VIP on guinea pig taenia coli requires the whole sequence.

作者信息

Pipkorn R, Håkanson R

出版信息

Peptides. 1984 Mar-Apr;5(2):267-9. doi: 10.1016/0196-9781(84)90217-1.

Abstract

Truncated sequences of VIP1-28 i.e., VIP1-6, VIP15-28 and VIP18-28, were synthesized. The biological activity of the peptides was tested on the isolated taenia coli from guinea-pig. Unlike VIP1-28, the truncated peptides had no effect alone or in combination. We also synthesized two peptides where VIP1-6 or VIP1-9 were joined with VIP20-28 or VIP21-28, respectively, with omission of the mid portion of VIP1-28. These peptides had no detectable biological activity. Finally, we synthesized Gly17,18,19-VIP, and tested it in the above mentioned system. It had a greatly reduced bioactivity compared with native VIP.

摘要

合成了VIP1 - 28的截短序列，即VIP1 - 6、VIP15 - 28和VIP18 - 28。在从豚鼠分离的结肠带绦虫上测试了这些肽的生物活性。与VIP1 - 28不同，这些截短的肽单独或联合使用均无作用。我们还合成了两种肽，其中VIP1 - 6或VIP1 - 9分别与VIP20 - 28或VIP21 - 28连接，省略了VIP1 - 28的中间部分。这些肽没有可检测到的生物活性。最后，我们合成了Gly17,18,19 - VIP，并在上述系统中进行了测试。与天然VIP相比，其生物活性大大降低。