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血管活性肠肽对豚鼠膀胱和结肠带的作用。

The effect of vasoactive intestinal polypeptide on the urinary bladder and taenia coli of the guinea pig.

作者信息

Johns A

出版信息

Can J Physiol Pharmacol. 1979 Jan;57(1):106-8. doi: 10.1139/y79-015.

DOI:10.1139/y79-015
PMID:427639
Abstract

The effect of vasoactive intestinal polypeptide (VIP) on the contractile activity of the urinary bladder and taenia coli of the guinea pig has been investigated. In the urinary bladder VIP caused a weak contraction and a small potentiation of the nerve-induced contraction. In the taenia coli VIP caused a small relaxation and had no effect on the nerve-induced relaxation of the preparation. The present experiments provide no evidence that VIP fulfills a role as a neurotransmitter in the urinary bladder or taenia coli, but it could be a modulator of transmitter action in the urinary bladder.

摘要

已对血管活性肠肽（VIP）对豚鼠膀胱和结肠带收缩活性的影响进行了研究。在膀胱中，VIP引起微弱收缩，并对神经诱导的收缩有轻微增强作用。在结肠带中，VIP引起轻微舒张，对该标本的神经诱导舒张无影响。目前的实验没有证据表明VIP在膀胱或结肠带中起神经递质的作用，但它可能是膀胱中递质作用的调节剂。

相似文献

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The effect of vasoactive intestinal polypeptide on the urinary bladder and taenia coli of the guinea pig.血管活性肠肽对豚鼠膀胱和结肠带的作用。
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Evidence against vasoactive intestinal polypeptide being the non-adrenergic, non-cholinergic inhibitory transmitter released from nerves supplying the smooth muscle of the guinea-pig taenia coli.关于血管活性肠肽并非从豚鼠结肠带平滑肌神经释放的非肾上腺素能、非胆碱能抑制性递质的证据。
Eur J Pharmacol. 1980 Oct 17;67(2-3):255-64. doi: 10.1016/0014-2999(80)90506-3.
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Evidence for and significance of the projection of VIP neurons from the myenteric plexus to the taenia coli in the guinea pig.豚鼠肌间神经丛中血管活性肠肽（VIP）神经元向结肠带投射的证据及意义。
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Suramin antagonizes responses to P2-purinoceptor agonists and purinergic nerve stimulation in the guinea-pig urinary bladder and taenia coli.苏拉明可拮抗豚鼠膀胱和平滑肌对P2嘌呤受体激动剂及嘌呤能神经刺激的反应。
Br J Pharmacol. 1990 Mar;99(3):617-21. doi: 10.1111/j.1476-5381.1990.tb12979.x.

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Effect of streptozotocin-induced diabetes mellitus on release of vasoactive intestinal polypeptide from rodent small intestine.链脲佐菌素诱导的糖尿病对啮齿动物小肠血管活性肠肽释放的影响。
Dig Dis Sci. 1995 Apr;40(4):828-36. doi: 10.1007/BF02064987.
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Central cholinergic mechanisms in L-DOPA induced hyperactive urinary bladder of the rat.
Urol Res. 1982;10(5):239-43. doi: 10.1007/BF00255929.
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Elevated levels of vasoactive intestinal peptide in the eye and urinary bladder of diabetic and prediabetic Chinese hamsters.糖尿病和糖尿病前期中国仓鼠的眼睛和膀胱中血管活性肠肽水平升高。
Diabetologia. 1985 May;28(5):302-7. doi: 10.1007/BF00271690.
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Non-cholinergic neurotransmission and the effects of peptides on the urinary bladder of guinea-pigs and rabbits.非胆碱能神经传递以及肽类对豚鼠和家兔膀胱的影响。
J Physiol. 1986 May;374:103-15. doi: 10.1113/jphysiol.1986.sp016068.