[热疗对静止生长期HeLa细胞早期辐射反应的作用]
[Action of hyperthermia on the early radiation reactions of HeLa cells in a stationary growth stage].
作者信息
Aleksandrova E N, Kalendo G S, Serebriakov N G
出版信息
Radiobiologiia. 1984 Jul-Aug;24(4):468-71.
A study was made of the influence of hyperthermia (42 degrees C, 30 min) after irradiation with a dose of 6 Gy on the permeability of cell membranes and the rate of incorporation of 3H-thymidine into DNA of HeLa cells at the stationary stage of the culture growth. Hyperthermia was shown to enhance the damaging effect of radiation on cells at this growth stage. It is suggested that this effect is connected with the impaired development of a series of early (during the first minutes and hours) adaptive reactions of HeLa cells, at the stationary stage of growth, to the effect of radiation.
研究了在培养生长静止期用6 Gy剂量照射后进行热疗（42摄氏度，30分钟）对细胞膜通透性以及3H-胸腺嘧啶核苷掺入HeLa细胞DNA速率的影响。结果表明，热疗会增强辐射对该生长阶段细胞的损伤作用。研究认为，这种效应与HeLa细胞在生长静止期对辐射作用的一系列早期（最初几分钟和几小时内）适应性反应发育受损有关。
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