Poulsen S S, Pedersen N T, Jarnum S
Scand J Gastroenterol. 1984 Jul;19(5):607-12.
Small (less than 1 mm), superficial erosions ('microerosions') have been observed stereo-microscopically in surface-stained rectal biopsies in Crohn's disease (CD). Biopsy specimens from 97 patients with CD, 225 with ulcerative colitis (UC), and a control material of 161 patients were investigated to define the occurrence and significance of the microerosions. In CD they were found in 13% of specimens, in UC in 5%, and in the control material not at all. In CD they were observed only in patients with colonic involvement and were most frequent (44%) in patients with this site of affection exclusively. Granulomas were identified in 62% of the biopsies with microerosions and by examination of two consecutive biopsies from each of these patients, in 85% indicating a positive correlation. In patients with microerosions and a primary diagnosis of UC, granulomas were found in 38% and by examination of two biopsies in 54%. Patients with granulomas and a few other patients were reclassified as CD, but there still remained some patients with microerosions, who most probably had UC. In conclusion, microerosions are observed mainly in CD with colonic involvement. There is a high incidence of granulomas in biopsy specimens with microerosions. The demonstration of microerosions in a specimen is suggestive of, but probably not diagnostic of, CD.
在克罗恩病（CD）患者经表面染色的直肠活检标本中，通过立体显微镜观察到了微小（小于1毫米）的浅表糜烂（“微糜烂”）。对97例CD患者、225例溃疡性结肠炎（UC）患者的活检标本以及161例对照材料进行了研究，以确定微糜烂的发生率及其意义。在CD患者中，13%的标本发现有微糜烂，UC患者中为5%，对照材料中则未发现。在CD患者中，微糜烂仅见于有结肠受累的患者，且在仅该部位受累的患者中最为常见（44%）。在62%有微糜烂的活检标本中发现了肉芽肿，对这些患者中的每一位进行连续两次活检检查，结果显示85%存在正相关。在初诊为UC且有微糜烂的患者中，38%的患者发现有肉芽肿，经两次活检检查发现54%有肉芽肿。有肉芽肿的患者以及其他一些患者被重新归类为CD，但仍有一些有微糜烂的患者，他们很可能患有UC。总之，微糜烂主要见于有结肠受累的CD患者。有微糜烂的活检标本中肉芽肿的发生率很高。标本中微糜烂的存在提示但可能不能确诊为CD。
