Spencer D L, Miller J A, Bertolini J E
Spine (Phila Pa 1976). 1984 May-Jun;9(4):422-6. doi: 10.1097/00007632-198405000-00018.
An instrumented probe mounted on the anterior surface of the lumbar spine over an excised lumbar intervertebral disc was used to stimulate a disc protrusion in 12 fresh cadavers. The contact force between probe and nerve root was measured as a function of two independent variables: probe protrusion depth and disc space height. The contact force on the nerve root was found to increase with increasing probe depth. Disc space widening increased the contact force while narrowing the disc space decreased it. A simple mechanical model analysis confirmed that the force exerted on the nerve root by the probe is the result of tension produced in the nerve root as it is deformed by the probe. The mechanical principle that disc narrowing can reduce the pressure on a nerve root produced by a disc protrusion may be an explanation of how chemonycleolysis relieves sciatic pain.
在12具新鲜尸体上，使用安装在切除的腰椎间盘前表面的仪器化探头来刺激椎间盘突出。探头与神经根之间的接触力作为两个独立变量的函数进行测量：探头突出深度和椎间盘间隙高度。发现随着探头深度增加，神经根上的接触力增大。椎间盘间隙增宽会增加接触力，而椎间盘间隙变窄则会降低接触力。一个简单的力学模型分析证实，探头施加在神经根上的力是神经根因探头变形而产生张力的结果。椎间盘变窄可减轻椎间盘突出对神经根产生的压力这一力学原理，可能解释了化学髓核溶解术如何缓解坐骨神经痛。
