Kohler T R, Kaufman J L, Kacoyanis G, Clowes A, Donaldson M C, Kelly E, Skillman J, Couch N P, Whittemore A D, Mannick J A
Surgery. 1984 Sep;96(3):462-6.
Recent clinical studies indicate that the use of aspirin and dipyridamole improves graft patency rates in patients with infrainguinal polytetrafluoroethylene (PTFE) grafts and aortocoronary vein grafts. We undertook a prospective, double-blind, randomized study to determine whether these drugs administered postoperatively to patients with PTFE or autologous vein infrainguinal bypasses would improve graft patency during the first 24 months after operation. Patients received either aspirin 325 mg and dipyridamole 75 mg or identical placebo tablets three times a day, taken orally. Patency rates were compared by computing standard life tables and comparing cumulative patency rates. One hundred patients with 102 grafts were studied. The cumulative patency rate at 24 months was not significantly different for the treatment (57%) versus control (67%) groups or for any subgroup. We conclude that aspirin and dipyridamole administered postoperatively in the doses used in this study do not improve the overall patency rates of vein or PTFE infrainguinal bypass grafts.
近期临床研究表明，阿司匹林和双嘧达莫的联用可提高接受腹股沟下聚四氟乙烯（PTFE）移植和主动脉冠状动脉静脉移植患者的移植血管通畅率。我们开展了一项前瞻性、双盲、随机研究，以确定在接受PTFE或自体静脉腹股沟下搭桥手术的患者术后使用这些药物是否会在术后24个月内提高移植血管通畅率。患者每天口服三次，每次服用阿司匹林325毫克和双嘧达莫75毫克或相同的安慰剂片剂。通过计算标准生命表并比较累积通畅率来比较通畅率。对100例患者的102条移植血管进行了研究。治疗组（57%）和对照组（67%）在24个月时的累积通畅率或任何亚组之间均无显著差异。我们得出结论，本研究中使用的剂量在术后给予阿司匹林和双嘧达莫并不能提高静脉或PTFE腹股沟下搭桥移植血管的总体通畅率。
