Inoue M, Yamada K, Ishida Y, Shinohara K, Kaneko T, Matsumoto N
Tohoku J Exp Med. 1984 Jun;143(2):213-20. doi: 10.1620/tjem.143.213.
The effect of peripheral mononuclear cells (MNCs), lymphocytes and sera of a patient with typical cyclic neutropenia (CN) upon the normal colony forming unit in culture (CFU-C) growth was examined. MNCs and lymphocytes obtained during the recovery phase of the cycles inhibited CFU-C growth. In contrast, these cells obtained during the neutropenic phase revealed no suppressive effect. Serum inhibitors of granulopoiesis were not detected at any time during the cycle. These findings suggest that MNCs, especially lymphocytes, may be one of the contributory factors for the development of CN in this case.
研究了一名典型周期性中性粒细胞减少症（CN）患者的外周血单个核细胞（MNCs）、淋巴细胞和血清对培养中的正常集落形成单位（CFU-C）生长的影响。在周期的恢复期获得的MNCs和淋巴细胞抑制CFU-C生长。相反，在中性粒细胞减少期获得的这些细胞未显示出抑制作用。在整个周期中任何时候均未检测到粒细胞生成的血清抑制剂。这些发现表明，MNCs，尤其是淋巴细胞，可能是该病例中CN发生的促成因素之一。
