Suda T, Mizoguchi H, Miura Y, Kubota K, Ikuta K, Sasaki H, Nagao T
Am J Pediatr Hematol Oncol. 1982 Summer;4(2):129-33.
Colony-forming capacities were studied in three Japanese children with Shwachman's syndrome (chronic neutropenia and exocrine pancreatic insufficiency). Bone marrow granulocyte-macrophage colony-forming cells assayed in a soft agar culture were markedly reduced in all three cases. The cytochemical examination of granulocyte-macrophage colonies by a new technique revealed that 90% of the colonies by a new technique revealed that 90% of the colonies consisted exclusively of granulocytes. Erythroid colony-forming cells assayed in a plasma clot culture were significantly reduced in two of the three cases. Bone marrow phagocytic cells did not suppress granulopoiesis in contrast to the cases of idiopathic aplastic anemia. Moreover, the patient serum did not inhibit granulopoiesis of normal bone marrow cells. These results have been discussed with the possibility of involving the hemopoietic stem cells and other additional factors.
对三名患有施瓦茨曼综合征（慢性中性粒细胞减少症和外分泌性胰腺功能不全）的日本儿童的集落形成能力进行了研究。在软琼脂培养中检测的骨髓粒细胞 - 巨噬细胞集落形成细胞在所有三例中均显著减少。通过一种新技术对粒细胞 - 巨噬细胞集落进行细胞化学检查发现，90%的集落仅由粒细胞组成。在血浆凝块培养中检测的红系集落形成细胞在三例中的两例中显著减少。与特发性再生障碍性贫血病例不同，骨髓吞噬细胞并未抑制粒细胞生成。此外，患者血清并未抑制正常骨髓细胞的粒细胞生成。已结合造血干细胞和其他额外因素的可能性对这些结果进行了讨论。
