Seki K, Uesato T, Kato K, Shima K
Acta Endocrinol (Copenh). 1984 Aug;106(4):433-6. doi: 10.1530/acta.0.1060433.
No nocturnal increase of prolactin (Prl) secretion during sleep has reportedly been discernible in most cases of hyperprolactinaemic patients with pituitary tumour. However, subjects previously evaluated, were in the majority, patients with large pituitary tumour. In the present study, 24 h secretory pattern of Prl was evaluated in 4 hyperprolactinaemic women with pituitary microadenoma and in 4 hyperprolactinaemic women with pituitary macroadenoma. Nocturnal increase of Prl secretion was observed in patients with microadenoma, but not in patients with macroadenoma. The nocturnal increase of Prl secretion in patients with microadenoma may reflect the function of the adenoma cells, and may suggest that the basic central nervous system programme governing Prl secretion in normals is qualitatively preserved in these patients. Alternatively, the nocturnal increase of Prl secretion may reflect the function of the normal lactotrophs remaining in these patients.
据报道，大多数垂体瘤所致高催乳素血症患者在睡眠期间催乳素（Prl）分泌并无夜间增加。然而，此前评估的对象多数为垂体大腺瘤患者。在本研究中，对4例垂体微腺瘤所致高催乳素血症女性和4例垂体大腺瘤所致高催乳素血症女性的Prl 24小时分泌模式进行了评估。微腺瘤患者观察到Prl分泌的夜间增加，而大腺瘤患者未观察到。微腺瘤患者Prl分泌的夜间增加可能反映腺瘤细胞的功能，也可能提示这些患者保留了正常情况下调节Prl分泌的基本中枢神经系统程序。另外，Prl分泌的夜间增加可能反映这些患者中残留的正常催乳素细胞的功能。
