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环境温度对正常及营养不良大鼠出生后早期发育过程中直肠温度的影响。

Effect of ambient temperature on rectal temperature in normal and malnourished rats during early postnatal development.

作者信息

Conradi N G, Müntzing K, Sourander P, Hamberger A

出版信息

Acta Physiol Scand. 1984 Jun;121(2):147-53. doi: 10.1111/j.1748-1716.1984.tb07441.x.

DOI:10.1111/j.1748-1716.1984.tb07441.x
PMID:6475545
Abstract

Information on body temperature is frequently lacking in metabolic studies on normal and malnourished suckling rats although differences in their thermoregulatory efficiency may be expected. The aim of the present study was to evaluate the effect of different ambient temperatures on the rectal temperature of litters of normal and protein deprived rats to establish the ambient temperatures at which a normal rectal temperature can be expected at various postnatal ages. The offspring of normal rats and rats subjected to a dietary reduction of 50% of the protein intake were examined 10 days to 30 days postnatally. The pups were transferred from the nest cage to an incubator: the rectal temperature was measured immediately after transfer to the incubator and 30 and 60 min later at ambient temperatures of 35, 30 and 25 degrees C. Up to 15 days of age control pups showed a fall in rectal temperature after the short exposure to room temperature (22 degrees C) needed for transfer. A similar fall of rectal temperature was recorded in the malnourished pups up to 25 days age. The effects of the ambient temperatures on the malnourished pups indicated a delay in the control of body temperature of some 10 days. This is in agreement with a previous report on semi-starved rats (Heim & Szelenyi 1965). The conditions for the maintenance of a normal rectal temperature in litters of normal and malnourished suckling rats separated from their mother are out-lined.

摘要

在对正常和营养不良的乳鼠进行的代谢研究中,常常缺乏有关体温的信息,尽管预计它们的体温调节效率会有所不同。本研究的目的是评估不同环境温度对正常和蛋白质缺乏大鼠窝仔直肠温度的影响,以确定在不同出生后年龄可预期正常直肠温度的环境温度。在出生后10天至30天检查正常大鼠的后代以及蛋白质摄入量减少50%的大鼠的后代。将幼崽从巢笼转移到孵化器中:在转移到孵化器后立即以及30分钟和60分钟后,在35、30和25摄氏度的环境温度下测量直肠温度。在15日龄之前,对照幼崽在短暂暴露于转移所需的室温(22摄氏度)后直肠温度会下降。在25日龄之前的营养不良幼崽中也记录到了类似的直肠温度下降。环境温度对营养不良幼崽的影响表明体温控制延迟了约10天。这与之前关于半饥饿大鼠的报告(Heim & Szelenyi,1965年)一致。文中概述了与母亲分离的正常和营养不良乳鼠窝仔维持正常直肠温度的条件。

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