Yarom A, Rennebohm R M, Strife F, Levinson J E
Am J Dis Child. 1984 Oct;138(10):955-7.
Two patients had onset of juvenile gouty arthritis at ages 16 and 1 1/2 years, respectively. Both had mild renal insufficiency, with creatinine clearances of 46 and 54 mL/min/1.73 sq m, respectively. Their presenting hyperuricemia (13.8 and 11 mg/dL, respectively) was out of proportion to the degree of renal insufficiency. Clinical and laboratory studies did not suggest an inborn error of purine metabolism, glycogen storage disease type I, or any myeloproliferative disorder. Neither patient had a family history of gout or inherited renal disease. Although juvenile gouty arthritis is rare, it must be considered in the differential diagnosis of episodic arthritis in children, especially if renal impairment, even mild, is present.
两名患者分别在16岁和1岁半时出现青少年痛风性关节炎。两人均有轻度肾功能不全，肌酐清除率分别为46和54 mL/min/1.73平方米。他们出现的高尿酸血症（分别为13.8和11 mg/dL）与肾功能不全的程度不相称。临床和实验室研究未提示嘌呤代谢先天性缺陷、I型糖原贮积病或任何骨髓增殖性疾病。两名患者均无痛风或遗传性肾病家族史。虽然青少年痛风性关节炎很少见，但在儿童发作性关节炎的鉴别诊断中必须考虑到，尤其是存在肾功能损害（即使是轻度）的情况下。
